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GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody, Biotin Conjugated

GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody, Biotin Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenGSK3 Alpha/Beta Tyr279+Tyr216
SpecificityThis is a highly specific antibody against GSK3 Alpha/Beta Tyr279+Tyr216
ModificationPhosphorylation
Modification siteTyr279+Tyr216
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range250-300/483
Subcellular location Cell membrane, Nucleus
SourceKLH conjugated synthetic phosphopeptide derived from human GSK3 Alpha/Beta around the phosphorylation site of Tyr279/Tyr216
Gene ID number29312932
Swiss ProtP49840
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background APC and AXIN1, CTNNB1/beta-catenin, Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis, Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease, In Wnt signaling, Is necessary for the establishment of neuronal polarity and axon outgrowth, May also mediate the development of insulin resistance by regulating activation of transcription factors, May be involved in the regulation of replication in pancreatic beta-cells, Regulates glycogen metabolism in liver, Requires primed phosphorylation of the majority of its substrates, Through phosphorylation of the anti-apoptotic protein MCL1, Wnt signaling and regulation of transcription factors and microtubules, but not in muscle, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), may control cell apoptosis in response to growth factors deprivation, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin, Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms GSK-3 alpha, GSK3A, Serine/threonine-protein kinase GSK3A, Glycogen synthase kinase-3 alpha
Description Conjugated is a &alpha, - or alpha protein sometimes glycoprotein present in blood, The GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetGSK3 Alpha/Beta(Tyr279+Tyr216) Conjugated
Short name Conjugated, GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, GSK3 a/b(Tyr279+Tyr216) (Antibody to)
Alternative techniqueantibodies

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