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Hamartin Antibody (TSC1)

Hamartin Antibody (TSC1) size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenHamartin (TSC1)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IF, IHC, WB
Recommended dilutionsIHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000
NotesTitration of the Hamartin antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis Hamartin antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q92574
PurityAntigen affinity
Description Clinical symptoms can range from benign hypopigmented macules of the skin to profound mental retardation with intractable seizures to premature death from a variety of disease-associated causes, Cortical dysplasias display a broad spectrum of structural changes, Defects in TSC1 are the cause of tuberous sclerosis complex (TSC), Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC), FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy, Interaction between TSC1 and TSC2 may facilitate vesicular docking, May have a function in vesicular transport, TSC is an autosomal dominant multi-system disorder that affects especially the brain, TSC is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (developmental abnormalities of tissue combination), The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex, and apoptosis of neuronal precursors and neurons during cortical development, and skin, differentiation, heart, kidneys, migration, which appear to result from changes in proliferation, Implicated as a tumor suppressor
ImmunogenA portion of amino acids 401-430 from the human protein was used as the immunogen for this Hamartin antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Hamartin antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetHamartin (TSC1)
Short nameHamartin Antibody (TSC1)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHamartin (Antibody to) (TSC1)
Alternative techniqueantibodies
Identity 12362
Gene TSC1
Long gene name tuberous sclerosis 1
Synonyms gene TSC
Synonyms KIAA0243 LAM hamartin
Locus 9q34
Discovery year 1986-01-01
GenBank acession AF013168
Pubmed identfication 9242607 10806479
Havana BLAST/BLAT OTTHUMG00000020844
Locus Specific Databases TSC Mutation Database Tuberous sclerosis database LRG_486

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