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HAMSTER ANTI HIGH MOBILITY GROUP PROTEIN B1 Antibody

HAMSTER ANTI HIGH MOBILITY GROUP PROTEIN B1 Antibody size: 100ug 525

Supplier MBS MONO
Price 525
Size 100ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Also known asHIGH MOBILITY GROUP PROTEIN B1
Other names Amphoterin, HMG-1, High mobility group protein 1, High mobility group protein B1, Sulfoglucuronyl carbohydrate binding protein, high mobility group box 1, high mobility group protein 1, high mobility group protein B1, high-mobility group (nonhistone chromosomal) protein 1, high-mobility group box 1, high mobility group protein B1
CategoryAntibodies
SubcategoryMnoclonal antibodies
Gene name HMG-1, HMG1, HMG1, HMG3, HMGB1, SBP-1, HMGB1
Gene name synonims HMG-1, HMG1, HMG1, HMG3, HMGB1, SBP-1, HMGB1
Other gene names HMG-1, HMG1, HMG1, HMG3, HMGB1, SBP-1, HMGB1
ClonalityMonoclonal
Immunoglobulin isotypeIgG
CloneHMG1-5H6
Host organismHamster
Species reactivity Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus)
Specificity and cross-reactivity Accelerated levels of HMGB1 are seen in several cancers and correlates with metastatic act, Cellular injury resulting in necrosis, DCs can also secrete HMGB1, It interacts directly with the autophagy protein Beclin-1, It is angiogenic and promotes cardiac stem cell growth and differentiation, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies have also shown that HMGB1 released after chemotherapy treatment is a critical regulator of autophagy, Studies identifying microtubule-associated protein 1 light chain 3 (LC3) lipidation and redistribution, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_HMGB1 is emerging as a prime specific marker and regulator of necrotic cell death, _x000D__x000D_HMGB1 is increasingly recognised as an important protein in medical research, _x000D__x000D_HMGB1 is one of the signature danger signals of endogenous cellular injury, a ubiquitously expressed nuclear DNA binding protein, and Toll-like receptors on macrophages, and a potential drug target for therapeutic interventions in leukemia, and binds to receptors, and facilitates transcription factor binding, and is also a prototypical damage-associated molecular pattern molecule (DAMP) which co-precipitates with CD24 and is associated with the hallmarks of cancer, and is released outside the cell by necrotic and inflammatory cells to act as a chemoattractant for immature dendritic cells (DCs), and microbes or pro-inflammatory cytokines may later stimulate active release from APCs, and one of a newly emerging group of alarmins, by bending DNA, coupled with the accumulation of autophagosomes and autolysosomes, have shown an important role for HMGB1 release in sustaining autophagy, it may act as an adjuvant or assist in tissue repair, leads to passive HMGB1 release, possibly through the PI3KC3-MEK-ERK pathway, promoting proliferation and Th1 polarization of interacting T cells, promoting their maturation, such as RAGE on endothelial cells, which acts as a stabilizer of nucleosome formation, HIGH MOBILITY GROUP PROTEIN B1 This item specifically recognises High mobility group protein B1 (HMGB1)
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
Concentration0mg/ml, IgG concentration 1
Storage and shipping If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term
Tested applications: Immunofluorescence (IF), Western Blot (WB), Flow Cytometry (FACS)
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
Gene targetMOBILITY GROUP PROTEIN B1
Short nameHAMSTER ANTI HIGH MOBILITY GROUP PROTEIN B1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHAMSTER antibody to HIGH MOBILITY family PROTEIN B1 (Antibody to)
Alternative techniqueantibodies

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