HAMSTER ANTI MOUSE CD339 Antibody

HAMSTER ANTI MOUSE CD339 Antibody size: 0.25 miligrams 437

Price 437

Size 0.25 miligrams

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Also known as	CD339
Other names	N/A, Protein jagged-1, jagged 1, protein jagged-1, protein jagged-1
Category	Antibodies
Subcategory	Mnoclonal antibodies
Gene name	CD339
Gene name synonims	N/A
Other gene names	Jag1, Jagged1, N/A, Jag1
Clonality	Monoclonal
Immunoglobulin isotype	IgG
Clone	HMJ1-29
Host organism	Hamster
Species reactivity	Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus)
Specificity and cross-reactivity	DLL3 and DLL4, Delta-like protein 1 (DLL1), Jagged1 (CD339), Jagged2, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies have shown a significant increase in the expression of Jagged1 in metastatic prostate cancer, Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), The canonical pathway inhibits the differentiation of stem cells or progenitor cells, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_In humans, _x000D__x000D_Jagged1 signaling is implicated in cell-fate decisions during hematopoiesis, _x000D__x000D_Ligation of Notch receptors by their specific ligands, _x000D__x000D_The Notch signaling pathway is an evolutionarily conserved pathway in multi-cellular organisms, and both tumor progression and suppression, and is involved in the inhibition of myoblast differentiation, as well as in both early and late stages of mammalian cardiovascular development, cardiac and endocrine development, compared with localized prostate cancer or benign prostatic tissues, implicating Jagged1 as a biomarker to facilitate their differentiation, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, induces proteolysis of the receptors by ADAM-family metalloproteases and the gamma-secretase complex, mutations in the JAG1 gene are responsible for the autosomal dominant multi-system developme, on physically adjacent signal receiving cells, one of the five major ligands of the Notch signaling pathway, or NF-kappaB-NICD and CSL-NICD-Deltex complex signaling cascades (non-canonical pathway), otherwise known as Jagged1, releasing the Notch intracellular domain (NICD) to translocate to the nucleus, stem cell hematopoiesis, thymic T-cell development, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4, which is vital for cell-cell communication, whilst the non-canonical pathway promotes differentiation, within the transmembrane domain, CD339 This item specifically recognises CD339
Purification method	N/A
Form/Appearance	Purified (Purified IgG - liquid)
Concentration	0mg/ml, IgG concentration 1
Storage and shipping	If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term
Tested applications:	Immunohistology - Frozen (IHC), Flow Cytometry (FACS)
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
Gene target	CD339
Short name	HAMSTER ANTI MOUSE CD339 Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	HAMSTER antibody to MOUSE CD339 (Antibody to)
Alternative technique	antibodies
Identity	6188
Gene	JAG1
Long gene name	jagged 1
Synonyms gene	AGS JAGL1
Synonyms gene name	Alagille syndrome
Synonyms	AHD AWS HJ1 CD339
Locus	20p12, 2
Discovery year	1997-05-22
GenBank acession	U61276
Entrez gene record	182
Pubmed identfication	7697721 9207788
RefSeq identity	NM_000214
Classification	CD molecules
Havana BLAST/BLAT	OTTHUMG00000031872
Locus Specific Databases	JAG1 database at LOVD-China

HAMSTER ANTI MOUSE CD339 Antibody

HAMSTER ANTI MOUSE CD339 Antibody size: 0.25 miligrams 437

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