HAMSTER ANTI MOUSE DELTA-LIKE PROTEIN 4 Antibody

HAMSTER ANTI MOUSE DELTA-LIKE PROTEIN 4 Antibody size: 0.25 miligrams 437

Price 437

Size 0.25 miligrams

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Also known as	DELTA-LIKE PROTEIN 4
Other names	Delta-like protein 4, Drosophila Delta homolog 4, delta-like 4 (Drosophila), delta-like protein 4, drosophila Delta homolog 4, delta-like protein 4
Category	Antibodies
Subcategory	Mnoclonal antibodies
Gene name	Delta4, Delta4, Dll4, Dll4
Gene name synonims	Delta4, Delta4, Dll4, Dll4
Other gene names	Delta4, Delta4, Dll4, Dll4
Clonality	Monoclonal
Immunoglobulin isotype	IgG
Clone	HMD4-2
Host organism	Hamster
Species reactivity	Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus)
Specificity and cross-reactivity	DLL3 and DLL4, DLL4 signaling has been shown to play a role in the angiogenesis of clear-cell renal tumors, Delta-like protein 1 (DLL1), Jagged1 (CD339), Jagged2, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies have shown that DLL4 expression in endothelium cells, Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), The canonical pathway inhibits the differentiation of stem cells or progenitor cells, This particular antibody might cross react with speacies outside of the listed ones, _x000D_Clone HMD4-2 has been shown to block mouse Notch1-Fc and Notch4-Fc binding to mou, _x000D_DLL4 is expressed by vascular endothelium, _x000D__x000D_Ligation of Notch receptors by their specific ligands, _x000D__x000D_The Notch signaling pathway is an evolutionarily conserved pathway in multi-cellular organisms, and both tumor progression and suppression, and by HIF1 alpha, and pancreatic, and plays a vital role in embryonic vascular development, and that blockade of DLL4 inhibits tumor growth by promoting non-productive angiogenesis, bladder and colonic cancer, can be up-regulated by vascular endothelial growth factor (VEGF) and basic-FGF, cardiac and endocrine development, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, induces proteolysis of the receptors by ADAM-family metalloproteases and the gamma-secretase complex, on physically adjacent signal receiving cells, one of the five major ligands of the Notch signaling pathway, or NF-kappaB-NICD and CSL-NICD-Deltex complex signaling cascades (non-canonical pathway), releasing the Notch intracellular domain (NICD) to translocate to the nucleus, stem cell hematopoiesis, thymic T-cell development, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4, which is vital for cell-cell communication, whilst the non-canonical pathway promotes differentiation, within the transmembrane domain, DELTA-LIKE PROTEIN 4 This item specifically recognises mouse Delta-like protein 4 (DLL4)
Purification method	N/A
Form/Appearance	Purified (Purified IgG - liquid)
Concentration	0mg/ml, IgG concentration 1
Storage and shipping	If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term
Tested applications:	Functional Assay (FA), Immunohistology - Frozen (IHC), Immunohistology - Paraffin (IHC), Flow Cytometry (FACS)
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
Gene target	DELTA-LIKE PROTEIN 4
Short name	HAMSTER ANTI MOUSE DELTA-LIKE PROTEIN 4 Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	HAMSTER antibody to MOUSE DELTA-LIKE PROTEIN 4 (Antibody to)
Alternative technique	antibodies

HAMSTER ANTI MOUSE DELTA-LIKE PROTEIN 4 Antibody

HAMSTER ANTI MOUSE DELTA-LIKE PROTEIN 4 Antibody size: 0.25 miligrams 437

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