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HAMSTER ANTI MOUSE NOTCH 2 Antibody

HAMSTER ANTI MOUSE NOTCH 2 Antibody size: 0.25 miligrams 437

Supplier MBS MONO
Price 437
Size 0.25 miligrams
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Also known asNOTCH 2
Other names Motch B, Motch B, Neurogenic locus notch homolog protein 2, Notch gene homolog 2, neurogenic locus notch homolog protein 2, notch 2, neurogenic locus notch homolog protein 2
CategoryAntibodies
SubcategoryMnoclonal antibodies
Gene nameNOTCH 2
Gene name synonimsN/A
Other gene names AI853703, N2, Notch 2, Notch2, Notch2
ClonalityMonoclonal
Immunoglobulin isotypeIgG
CloneHMN2-35
Host organismHamster
Species reactivity Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus)
Specificity and cross-reactivity DLL3 and DLL4, Delta-like protein 1 (DLL1), Jagged1 (CD339), Jagged2, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies have also shown a correlation between a decrease in Notch 2 expression and an increase in grade of human breast cancer, Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), The canonical pathway inhibits the differentiation of stem cells or progenitor cells, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Clone HMN2-35 has been shown to cross-react with rat mast cell line RBL-2H3 and Y3 myeloma cells, _x000D__x000D_Ligation of Notch receptors by their specific ligands, _x000D__x000D_Signaling through Notch 2 has been implicated in the development of marginal zone B cells (MZB), _x000D__x000D_The Notch signaling pathway is an evolutionarily conserved pathway in multi-cellular organisms, and both tumor progression and suppression, and the regulation of the expression of CD23 in B-cell lymphocytic leukemia (B-CLL), cardiac and endocrine development, important during fundamental developmental and physiological processes, in flow cytometry, including regulation of cell fate decisions during neuronal, induces proteolysis of the receptors by ADAM-family metalloproteases and the gamma-secretase complex, on physically adjacent signal receiving cells, one of the four major transmembrane receptors (Notch 1-4) of the Notch signaling pathway, or NF-kappaB-NICD and CSL-NICD-Deltex complex signaling cascades (non-canonical pathway), releasing the Notch intracellular domain (NICD) to translocate to the nucleus, stem cell hematopoiesis, the sensitization of endothelial cells to apoptosis, thymic T-cell development, which is activated through binding to DSL domain-containing membrane-bound specific ligands, which is vital for cell-cell communication, whilst the non-canonical pathway promotes differentiation, within the transmembrane domain, NOTCH 2 This item specifically recognises Notch 2
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
Concentration0mg/ml, IgG concentration 1
Storage and shipping If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term
Tested applications:Flow Cytometry (FACS)
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
Gene targetNOTCH 2
Short nameHAMSTER ANTI MOUSE NOTCH 2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHAMSTER antibody to MOUSE NOTCH 2 (Antibody to)
Alternative techniqueantibodies
Identity 31862
Gene NOTCH2NL
Long gene name notch 2 N-terminal like
Synonyms gene name Notch homolog 2 (Drosophila) N-terminal like
Synonyms N2N
Locus 1q21, 1
Discovery year 2004-12-02
Entrez gene record 388677
Pubmed identfication 14673143
RefSeq identity NM_203458
Havana BLAST/BLAT OTTHUMG00000013754

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