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HAMSTER ANTI MOUSE NOTCH 2:RPE Antibody

HAMSTER ANTI MOUSE NOTCH 2:RPE Antibody size: 100 Tests 310

Supplier MBS MONO
Price 310
Size 100 Tests
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Also known asNOTCH 2
Other names Motch B, Motch B, Neurogenic locus notch homolog protein 2, Notch gene homolog 2, neurogenic locus notch homolog protein 2, notch 2, neurogenic locus notch homolog protein 2
CategoryAntibodies
SubcategoryMnoclonal antibodies
Gene nameNOTCH 2
Gene name synonimsN/A
Other gene names AI853703, N2, Notch 2, Notch2, Notch2
ClonalityMonoclonal
Immunoglobulin isotypeIgG
CloneHMN2-35
Host organismHamster
Species reactivity Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus)
Specificity and cross-reactivity DLL3 and DLL4, Delta like-1 (DLL1), Jagged1 (CD339), Jagged2, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies have also shown a correlation between a decrease in Notch 2 expression and an increase in grade of human breast cancer, Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), The canonical pathway inhibits the differentiation of stem cells or progenitor cells, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Clone HMN2-35 has been shown to cross-react with rat mast cell line RBL-2H3 and Y3 myeloma cells, _x000D__x000D_Ligation of Notch receptors by their specific ligands, _x000D__x000D_Signalling through Notch 2 has been implicated in the development of marginal zone B cells (MZB), _x000D__x000D_The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, and both tumour progression and suppression, and the regulation of the expression of CD23 in B-cell lymphocytic leukaemia (B-CLL), cardiac and endocrine development, important during fundamental developmental and physiological processes, in flow cytometry, including regulation of cell fate decisions during neuronal, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, on physically adjacent signal receiving cells, one of the four major transmembrane receptors (Notch 1-4) of the Notch signalling pathway, or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway), releasing the Notch intracellular domain (NICD) to translocate to the nucleus, stem cell haematopoiesis, the sensitization of endothelial cells to apoptosis, thymic T-cell development, which is activated through binding to DSL domain-containing membrane-bound specific ligands, which is vital for cell-cell communication, whilst the non-canonical pathway promotes differentiation, within the transmembrane domain, NOTCH 2 Clone HMN2-35 specifically recognises Notch 2
Purification methodN/A
Form/Appearance Phycoerythrin (RPE) - lyophilised), RPE (Purified IgG conjugated to R
ConcentrationN/A
Storage and shipping After reconstitution Keep the antibody refrigerated at +4 degrees Celsius, DO NOT FREEZE, If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Shelf Life: 12 months from date of reconstitution, Temperature variations in the range between +1C to +7C are tolerable, Temperature variations in the range between +1C to +7C are tolerable, the antibody is photosensitive and should be protected from light, the antibody should be stored undiluted, Prior to reconstitution Keep the antibody refrigerated at +4 degrees Celsius
Tested applications:Flow Cytometry (FACS)
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
Gene targetNOTCH 2:RPE
Short nameHAMSTER ANTI MOUSE NOTCH 2:RPE Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHAMSTER antibody to MOUSE NOTCH 2:RPE (Antibody to)
Alternative techniqueantibodies
Identity 10293
Gene RPE
Long gene name ribulose-5-phosphate-3-epimerase
Locus 2q34
Discovery year 2001-06-22
Entrez gene record 6120
RefSeq identity NM_006916
Havana BLAST/BLAT OTTHUMG00000154690

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