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HAMSTER ANTI MOUSE NOTCH 3 Antibody

HAMSTER ANTI MOUSE NOTCH 3 Antibody size: 100ug 277

Supplier MBS MONO
Price 277
Size 100ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Also known asNOTCH 3
Other names N/A, Neurogenic locus notch homolog protein 3, Notch gene homolog 3, neurogenic locus notch homolog protein 3, notch 3, neurogenic locus notch homolog protein 3
CategoryAntibodies
SubcategoryMnoclonal antibodies
Gene nameNOTCH 3
Gene name synonimsN/A
Other gene names N/A, Notch 3, Notch3, Notch3
ClonalityMonoclonal
Immunoglobulin isotypeIgG
CloneHMN3-133
Host organismHamster
Species reactivity Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus)
Specificity and cross-reactivity DLL3 and DLL4, Delta-like protein 1 (DLL1), Jagged1 (CD339), Jagged2, Notch 3 is also present on some thymocytes subsets and Treg cells, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies have implicated the over-expression of Notch 3 in T-cell leukaemia, Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), The canonical pathway inhibits the differentiation of stem cells or progenitor cells, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_In humans, _x000D__x000D_Ligation of Notch receptors by their specific ligands, _x000D__x000D_Notch 3 is primarily expressed by proliferating neuroepithelium and arterial smooth muscle cells, _x000D__x000D_The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, and Notch 3 signalling plays a role in mammalian T cell lineage commitment, and both tumour progression and suppression, and may play a role during CNS development, and stem cell haematopoiesis, cardiac and endocrine development, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, mutations in the NOTCH3 gene are responsible for the heritable vascular dementia known as CADASIL (cerebral autosomal dominant arteriopathy, on physically adjacent signal receiving cells, one of the four major transmembrane receptors (Notch 1-4) of the Notch signalling pathway, or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway), releasing the Notch intracellular domain (NICD) to translocate to the nucleus, stem cell haematopoiesis, thymic T-cell development, thymocyte development, which is activated through binding to DSL domain-containing membrane-bound specific ligands, which is vital for cell-cell communication, whilst the non-canonical pathway promotes differentiation, within the transmembrane domain, NOTCH 3 This item specifically recognises Notch 3
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
Concentration0mg/ml, IgG concentration 1
Storage and shipping If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term
Tested applications:Flow Cytometry (FACS)
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
Gene targetNOTCH 3
Short nameHAMSTER ANTI MOUSE NOTCH 3 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHAMSTER antibody to MOUSE NOTCH 3 (Antibody to)
Alternative techniqueantibodies
Identity 7883
Gene NOTCH3
Long gene name notch 3
Synonyms gene CADASIL
Synonyms gene name Notch (Drosophila) homolog 3 Notch homolog 3 (Drosophila)
Synonyms CASIL
Locus 19p13, 12
Discovery year 1994-07-04
GenBank acession U97669
Entrez gene record 4854
Pubmed identfication 7835890
RefSeq identity NM_000435
Classification Ankyrin repeat domain containing
Havana BLAST/BLAT OTTHUMG00000183217
Locus Specific Databases NOTCH3 - CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical LOVD - Leiden Open Variation Database

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