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HAUSP Antibody

HAUSP Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHAUSP Primary Polyclonal Antibody
Also known asHAUSP PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHAUSP
SpecificityThis is a highly specific antibody against HAUSP
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range850-900/1102
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HAUSP/USP7
Gene ID number7874
Swiss ProtQ93009
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection, DNMT1, Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity, ERCC6, Exhibits a preference towards 'Lys-48'-linked ubiquitin chains, In association with DAXX, Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222), Involved in cell proliferation during early embryonic development, Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, MDM2, PTEN and DAXX, Together with DAXX, UHRF1, and also induces p53/TP53-dependent cell growth repression and apoptosis, both processes that are counteracted by PML, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, p53/TP53, preventing UV-induced degradation of ERCC6, preventing their degradation and promoting DNA methylation by DNMT1, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation, Hydrolase that deubiquitinates target proteins such as FOXO4
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Deubiquitinating enzyme 7, HAUSP, Herpesvirus-associated ubiquitin-specific protease, USP7, Ubiquitin carboxyl-terminal hydrolase 7, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7, TEF1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHAUSP
Short nameHAUSP Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHAUSP (Antibody to)
Alternative techniqueantibodies
Identity 12630
Gene USP7
Long gene name ubiquitin specific peptidase 7
Synonyms gene HAUSP
Synonyms gene name ubiquitin specific peptidase 7 (herpes virus-associated)
Locus 16p13, 2
Discovery year 1998-10-12
GenBank acession Z72499
Entrez gene record 7874
Pubmed identfication 12838346 9925944
Classification Ubiquitin specific peptidases
Havana BLAST/BLAT OTTHUMG00000176903

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