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HCF2 Antibody

HCF2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHCF2 Primary Polyclonal Antibody
Also known asHCF2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHCF2
SpecificityThis is a highly specific antibody against HCF2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HCF2/Heparin Cofactor II
Gene ID number3053
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Also inhibits chymotrypsin, Defects in SERPIND1 are the cause of Heparin Cofactor II deficiency, Heparin Cofactor II becomes the predominant thrombin inhibitor in place of antithrombin III (AT III), Heparin Cofactor II deficiency is an important risk factor for hereditary thrombophilia, Heparin Cofactor II deficiency is inherited as an autosomal dominant disorder, Heparin Cofactor II is antigenically distinct from AT III, Heparin Cofactor II is normal in patients with AT III deficiency and is low in patients with disseminated intravascular coagulation, In the presence of the latter, It is expressed predominantly in liver, Its function is: thrombin inhibitor activated by the glycosaminoglycans, The N terminal acidic repeat region mediates, The first of these to be well characterized was antithrombin III, a multifactorial trait characterized by recurrent thrombosis and abnormal platelet aggregation in response to various agents, a viral transcription factor that activates the viral immediate-early (IE) genes, but in a glycosaminoglycan independent manner and peptides at the N terminal of Heparin Cofactor II have chemotactic activity for both monocytes and neutrophils, heparin or dermatan sulfate, in part, in which affected individuals are prone to develop serious spontaneous thrombosis, the glycosaminoglycan accelerated thrombin inhibition, The anticoagulant action of heparin is dependent on plasma components termed heparin cofactors, The herpes simplex virus (HSV) infection is initiated by VP16
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names HCF2, HEP2_HUMAN, HLS2, LS2, Leuserpin 2, Protease inhibitor leuserpin 2, SERPIND1, HC II
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHCF2
Short nameHCF2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHCF2 (Antibody to)
Alternative techniqueantibodies
Identity 4838
Gene SERPIND1
Long gene name serpin family D member 1
Synonyms gene HCF2
Synonyms gene name clade D (heparin cofactor), clade D (heparin cofactor), member 1 , member 1 serpin peptidase inhibitor, serine (or cysteine) proteinase inhibitor
Synonyms HC-II HLS2 HC2 D22S673
Synonyms name heparin cofactor II heparin cofactor 2
Locus 22q11, 21
Discovery year 1988-05-31
GenBank acession M12849
Entrez gene record 3053
Pubmed identfication 1671335 24172014
RefSeq identity NM_000185
Classification Serpin peptidase inhibitors
Havana BLAST/BLAT OTTHUMG00000150755
Locus Specific Databases LRG_594

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