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HCN2 + HCN4 Antibody

HCN2 + HCN4 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHCN2 + HCN4 Primary Polyclonal Antibody
Also known asHCN2 + HCN4 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHCN2 + HCN4
SpecificityThis is a highly specific antibody against HCN2 + HCN4
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HCN2 + HCN4
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen HCN currents have been linked to pacemaker activity in the heart and brain, HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells, HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides, HCN2 is highly abundant in mamillary bodies, HCN4 is another member of the family of hyperpolarization activated and cyclic nucleotide gated channels, It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node, and nucleus of the trapezoid body, as well as, as well as neuronal plasticity, contribute to spontaneous rhythmic activity in both heart and brain, pontine nucleus, resting potential control, shaping autonomous activity of single neurons and the periodicity of network oscillations, ventral cochlear nucleus, Hyperpolarization activated cation channels of the HCN gene family such as HCN2
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Brain cyclic nucleotide gated channel 2, HAC 1, HCN 2, HCN 4, HCN4_HUMAN, Hyperpolarization activated cyclic nucleotide gated potassium channel 4, BCNG 2, HCN2_HUMAN
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHCN2 + HCN4
Short nameHCN2 + HCN4 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHCN2 and HCN4 (Antibody to)
Alternative techniqueantibodies
Identity 16882
Gene HCN4
Long gene name hyperpolarization activated cyclic nucleotide gated potassium channel 4
Synonyms gene name hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Locus 15q24, 1
Discovery year 2002-09-02
GenBank acession AJ132429
Entrez gene record 10021
Pubmed identfication 10228147 10430953 16382102
RefSeq identity NM_005477
Classification Cyclic nucleotide gated channels
Havana BLAST/BLAT OTTHUMG00000137563

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