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HCN2 + HCN4 Antibody, Biotin Conjugated

HCN2 + HCN4 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, HCN2 + HCN4 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenHCN2 + HCN4
SpecificityThis is a highly specific antibody against HCN2 + HCN4
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human HCN2 + HCN4
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background HCN currents have been linked to pacemaker activity in the heart and brain, HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells, HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides, HCN2 is highly abundant in mamillary bodies, HCN4 is another member of the family of hyperpolarization activated and cyclic nucleotide gated channels, It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node, and nucleus of the trapezoid body, as well as, as well as neuronal plasticity, contribute to spontaneous rhythmic activity in both heart and brain, pontine nucleus, resting potential control, shaping autonomous activity of single neurons and the periodicity of network oscillations, ventral cochlear nucleus, Hyperpolarization activated cation channels of the HCN gene family such as HCN2
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetHCN2 + HCN4 Conjugated
Short name Conjugated, HCN2 + HCN4 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, HCN2 and HCN4 (Antibody to)
Alternative techniqueantibodies
Identity 16882
Gene HCN4
Long gene name hyperpolarization activated cyclic nucleotide gated potassium channel 4
Synonyms gene name hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Locus 15q24, 1
Discovery year 2002-09-02
GenBank acession AJ132429
Entrez gene record 10021
Pubmed identfication 10228147 10430953 16382102
RefSeq identity NM_005477
Classification Cyclic nucleotide gated channels
Havana BLAST/BLAT OTTHUMG00000137563

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