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HCST Antibody

HCST Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHCST Primary Polyclonal Antibody
Also known asHCST PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHCST
SpecificityThis is a highly specific antibody against HCST
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range1-50/93
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HCST
Gene ID number10870
Swiss ProtQ9UBK5
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells, Functions as docking site for PI3-kinase PIK3R1 and GRB2, In NK cells, In T-cells, Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors, MAP2K/ERK, and JAK2/STAT5 signaling pathways, and UL16-binding proteins (ULBPs), indeed, it provides primarily costimulation for TCR-induced signals, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells, these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation, this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DNAX-activation protein 10, HCST, Hematopoietic cell signal transducer, KAP10, Membrane protein DAP10, PIK3AP, Transmembrane adapter protein KAP10, UNQ587/PRO1157, DAP10
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHCST
Short nameHCST Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHCST (Antibody to)
Alternative techniqueantibodies
Identity 11021
Gene SLC35A1
Long gene name solute carrier family 35 member A1
Synonyms gene name member 1 solute carrier family 35 (CMP-sialic acid transporter), member A1 , solute carrier family 35 (UDP-galactose transporter)
Synonyms CMPST hCST
Locus 6q15
Discovery year 1999-10-05
GenBank acession D87969
Entrez gene record 10559
Pubmed identfication 9010752 9644260
Classification Solute carriers
Havana BLAST/BLAT OTTHUMG00000015177

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