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HCST Antibody, ALEXA FLUOR 555

HCST Antibody, ALEXA FLUOR 555 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 555 Conjugated, HCST Polyclonal Antibody
Also known asAnti-HCST PAb ALEXA FLUOR 555
CategoryConjugated Primary Antibodies
Conjugated with 555, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenHCST
SpecificityThis is a highly specific antibody against HCST
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range1-50/93
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HCST
Gene ID Number10870
Swiss ProtQ9UBK5
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
CrossreactivityHuman
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells, Functions as docking site for PI3-kinase PIK3R1 and GRB2, In NK cells, In T-cells, Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors, MAP2K/ERK, and JAK2/STAT5 signaling pathways, and UL16-binding proteins (ULBPs), indeed, it provides primarily costimulation for TCR-induced signals, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells, these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation, this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission553nm/568nm
Synonyms CMPST hCST
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 555, Alexa Fluor
Gene targetHCST
Short nameHCST Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 555
Alternative name ALEXA FLUOR 555, HCST (Antibody to)
Alternative techniqueantibodies
Identity 11021
Gene SLC35A1
Long gene name solute carrier family 35 member A1
Synonyms gene name member 1 solute carrier family 35 (CMP-sialic acid transporter), member A1 , solute carrier family 35 (UDP-galactose transporter)
Locus 6q15
Discovery year 1999-10-05
GenBank acession D87969
Entrez gene record 10559
Pubmed identfication 9010752 9644260
Classification Solute carriers
Havana BLAST/BLAT OTTHUMG00000015177

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