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HCST Antibody, Cy3 Conjugated

HCST Antibody, Cy3 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy3 Conjugated, HCST Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugationcy3 conjugation kit
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenHCST
SpecificityThis is a highly specific antibody against HCST
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range1-50/93
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human HCST
Gene ID number10870
Swiss ProtQ9UBK5
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
CrossreactivityHuman
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells, Functions as docking site for PI3-kinase PIK3R1 and GRB2, In NK cells, In T-cells, Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors, MAP2K/ERK, and JAK2/STAT5 signaling pathways, and UL16-binding proteins (ULBPs), indeed, it provides primarily costimulation for TCR-induced signals, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells, these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation, this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission512, 550nm/570, 615nm
Synonyms CMPST hCST
Properties 1 of the HCST Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetHCST Conjugated
Short name Conjugated, HCST Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy3
Alternative name cyanine 3 coupled, HCST (Antibody to)
Alternative techniqueantibodies
Identity 11021
Gene SLC35A1
Long gene name solute carrier family 35 member A1
Synonyms gene name member 1 solute carrier family 35 (CMP-sialic acid transporter), member A1 , solute carrier family 35 (UDP-galactose transporter)
Locus 6q15
Discovery year 1999-10-05
GenBank acession D87969
Entrez gene record 10559
Pubmed identfication 9010752 9644260
Classification Solute carriers
Havana BLAST/BLAT OTTHUMG00000015177

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