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HDAC3 Antibody

HDAC3 Antibody size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenHDAC3
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC, WB
Recommended dilutionsIHC (Paraffin): 1:10-1:50, Western blot: 1:1000
NotesTitration of the HDAC3 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis HDAC3 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #O15379
PurityAntigen affinity
Description Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA, It has histone deacetylase activity and represses transcription when tethered to a promoter, It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1, The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family, This gene is regarded as a potential tumor suppressor gene, This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis, [provided by RefSeq], and developmental events, cell cycle progression, Histones play a critical role in transcriptional regulation
ImmunogenA portion of amino acids 383-412 from the human protein was used as the immunogen for this HDAC3 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the HDAC3 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetHDAC3
Short nameHDAC3 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namehistone deacetylase 3 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target DNA-templated and biological process this GO :0006476 and protein deacetylation and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007346 and regulation of mitotic cell cycle and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008152 and metabolic process and biological process this GO :0016568 and chromatin modification and biological process this GO :0016575 and histone deacetylation and biological process this GO :0016787 and hydrolase activity and molecular function this GO :0017053 and transcriptional repressor complex and cellular component this GO :0019899 and enzyme binding and molecular function this GO :0030332 and cyclin binding and molecular function this GO :0031490 and chromatin DNA binding and molecular function this GO :0032041 and NAD-dependent histone deacetylase activity (H3-K14 specific) and molecular function this GO :0032922 and circadian regulation of gene expression and biological process this GO :0033558 and protein deacetylase activity and molecular function this GO :0040014 and regulation of multicellular organism growth and biological process this GO :0042826 and histone deacetylase binding and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0044255 and cellular lipid metabolic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0045786 and negative regulation of cell cycle and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0046329 and negative regulation of JNK cascade and biological process this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0046970 and NAD-dependent histone deacetylase activity (H4-K16 specific) and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0051225 and spindle assembly and biological process this GO :0070932 and histone H3 deacetylation and biological process this GO :0070933 and histone H4 deacetylation and biological process this GO :0097372 and NAD-dependent histone deacetylase activity (H3-K18 specific) and molecular function, HD3 and RPD3 and RPD3-2, HDAC3 and IDBG-50725 and ENSG00000171720 and 8841, HDAC3 and IDBG-646121 and ENSBTAG00000017360 and 404125, Hdac3 and IDBG-140814 and ENSMUSG00000024454 and 15183, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, this GO :0000118 and histone deacetylase complex and cellular component this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005876 and spindle microtubule and cellular component this GO :0006351 and transcription, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003682: chromatin binding and also this GO :0003714: transcription corepressor activity and also this GO :0004407: histone deacetylase activity and also this GO :0005515: protein binding and also this GO :0008134: transcription factor binding and also this GO :0016787: hydrolase activity and also this GO :0019899: enzyme binding and also this GO :0030332: cyclin binding and also this GO :0031490: chromatin DNA binding and also this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific) and also this GO :0033558: protein deacetylase activity and also this GO :0042826: histone deacetylase binding and also this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific) and also this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0003682: chromatin binding, this GO :0003714: transcription corepressor activity, this GO :0004407: histone deacetylase activity, this GO :0005515: protein binding, this GO :0008134: transcription factor binding, this GO :0016787: hydrolase activity, this GO :0019899: enzyme binding, this GO :0030332: cyclin binding, this GO :0031490: chromatin DNA binding, this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific), this GO :0033558: protein deacetylase activity, this GO :0042826: histone deacetylase binding, this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific), this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), histone deacetylase 3
Identity 4854
Gene HDAC3
Long gene name histone deacetylase 3
Synonyms RPD3 HD3 RPD3-2
Locus 5q31, 3
Discovery year 1999-01-29
GenBank acession AF059650
Entrez gene record 8841
Pubmed identfication 9501169 9464271
RefSeq identity NM_003883
Classification Histone deacetylases, class I
Havana BLAST/BLAT OTTHUMG00000129629

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