| Background of the antigen | Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA, It also interacts with myocyte enhancer factor-2 (MEF2) proteins, It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins, It possesses histone deacetylase activity and represses transcription when tethered to a promoter, The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family, This gene is thought to be associated with colon cancer, Two transcript variants encoding different isoforms have been found for this gene, [provided by RefSeq], and developmental events, cell cycle progression, resulting in repression of MEF2-dependent genes, Histones play a critical role in transcriptional regulation |
| Alternative to gene target | AHO3 and BDMR and HA6116 and HD4 and HDAC-4 and HDAC-A and HDACA, DNA-templated and biological process this GO :0006954 and inflammatory response and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007507 and heart development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0010830 and regulation of myotube differentiation and biological process this GO :0010832 and negative regulation of myotube differentiation and biological process this GO :0016568 and chromatin modification and biological process this GO :0016575 and histone deacetylation and biological process this GO :0016604 and nuclear body and cellular component this GO :0030183 and B cell differentiation and biological process this GO :0032041 and NAD-dependent histone deacetylase activity (H3-K14 specific) and molecular function this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0033555 and multicellular organismal response to stress and biological process this GO :0042113 and B cell activation and biological process this GO :0042220 and response to cocaine and biological process this GO :0042493 and response to drug and biological process this GO :0043234 and protein complex and cellular component this GO :0043393 and regulation of protein binding and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0006954 and inflammatory response and biological process this GO :0007399 and nervous system development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0010832 and negative regulation of myotube differentiation and biological process this GO :0010882 and regulation of cardiac muscle contraction by calcium ion signaling and biological process this GO :0014894 and response to denervation involved in regulation of muscle adaptation and biological process this GO :0014898 and cardiac muscle hypertrophy in response to stress and biological process this GO :0016568 and chromatin modification and biological process this GO :0016575 and histone deacetylation and biological process this GO :0017053 and transcriptional repressor complex and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0030017 and sarcomere and cellular component this GO :0030018 and Z disc and cellular component this GO :0030183 and B cell differentiation and biological process this GO :0030955 and potassium ion binding and molecular function this GO :0031594 and neuromuscular junction and cellular component this GO :0031672 and A band and cellular component this GO :0032041 and NAD-dependent histone deacetylase activity (H3-K14 specific) and molecular function this GO :0033235 and positive regulation of protein sumoylation and biological process this GO :0033558 and protein deacetylase activity and molecular function this GO :0033613 and activating transcription factor binding and molecular function this GO :0034983 and peptidyl-lysine deacetylation and biological process this GO :0042113 and B cell activation and biological process this GO :0042493 and response to drug and biological process this GO :0042641 and actomyosin and cellular component this GO :0042826 and histone deacetylase binding and molecular function this GO :0043234 and protein complex and cellular component this GO :0043393 and regulation of protein binding and biological process this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045820 and negative regulation of glycolytic process and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0007043 and cell-cell junction assembly and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0016568 and chromatin modification and biological process this GO :0016575 and histone deacetylation and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0032041 and NAD-dependent histone deacetylase activity (H3-K14 specific) and molecular function this GO :0032703 and negative regulation of interleukin-2 production and biological process this GO :0033613 and activating transcription factor binding and molecular function this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0046872 and metal ion binding and molecular function this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0046970 and NAD-dependent histone deacetylase activity (H4-K16 specific) and molecular function this GO :0070491 and repressing transcription factor binding and molecular function this GO :0070932 and histone H3 deacetylation and biological process this GO :0070933 and histone H4 deacetylation and biological process this GO :0071889 and 14-3-3 protein binding and molecular function this GO :0090050 and positive regulation of cell migration involved in sprouting angiogenesis and biological process this GO :0097372 and NAD-dependent histone deacetylase activity (H3-K18 specific) and molecular function, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046872 and metal ion binding and molecular function this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0046970 and NAD-dependent histone deacetylase activity (H4-K16 specific) and molecular function this GO :0048742 and regulation of skeletal muscle fiber development and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051153 and regulation of striated muscle cell differentiation and biological process this GO :0070491 and repressing transcription factor binding and molecular function this GO :0070932 and histone H3 deacetylation and biological process this GO :0070933 and histone H4 deacetylation and biological process this GO :0090051 and negative regulation of cell migration involved in sprouting angiogenesis and biological process this GO :0097372 and NAD-dependent histone deacetylase activity (H3-K18 specific) and molecular function, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0046970 and NAD-dependent histone deacetylase activity (H4-K16 specific) and molecular function this GO :0048742 and regulation of skeletal muscle fiber development and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051153 and regulation of striated muscle cell differentiation and biological process this GO :0070491 and repressing transcription factor binding and molecular function this GO :0070555 and response to interleukin-1 and biological process this GO :0070932 and histone H3 deacetylation and biological process this GO :0070933 and histone H4 deacetylation and biological process this GO :0097372 and NAD-dependent histone deacetylase activity (H3-K18 specific) and molecular function, HD5 and NY-CO-9, HDAC4 and IDBG-642244 and ENSBTAG00000017764 and 517559, HDAC4 and IDBG-84594 and ENSG00000068024 and 9759, HDAC5 and IDBG-53295 and ENSG00000108840 and 10014, HDAC5 and IDBG-640847 and ENSBTAG00000016254 and 504242, HDAC7 and IDBG-29060 and ENSG00000061273 and 51564, HDAC7 and IDBG-633011 and ENSBTAG00000026819 and 509843, Hdac4 and IDBG-181579 and ENSMUSG00000026313 and 208727, Hdac5 and IDBG-212520 and ENSMUSG00000008855 and 15184, Hdac7 and IDBG-179042 and ENSMUSG00000022475 and 56233, NAD-dependent histone deacetylase activity (H3-K18 specific), NAD-dependent histone deacetylase activity (H3-K18 specific), NAD-dependent histone deacetylase activity (H3-K18 specific), histone deacetylase 4, histone deacetylase 5, nuclei, nuclei, nuclei, this GO :0000118 and histone deacetylase complex and cellular component this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001047 and core promoter binding and molecular function this GO :0001501 and skeletal system development and biological process this GO :0002076 and osteoblast development and biological process this GO :0003677 and DNA binding and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006338 and chromatin remodeling and biological process this GO :0006351 and transcription, this GO :0000118 and histone deacetylase complex and cellular component this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001570 and vasculogenesis and biological process this GO :0003682 and chromatin binding and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006351 and transcription, this GO :0000118 and histone deacetylase complex and cellular component this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0002076 and osteoblast development and biological process this GO :0003714 and transcription corepressor activity and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0006325 and chromatin organization and biological process this GO :0006338 and chromatin remodeling and biological process this GO :0006342 and chromatin silencing and biological process this GO :0006351 and transcription, this GO :0001047: core promoter binding, this GO :0001047: core promoter binding and also this GO :0003677: DNA binding and also this GO :0003714: transcription corepressor activity and also this GO :0004407: histone deacetylase activity and also this GO :0005515: protein binding and also this GO :0008134: transcription factor binding and also this GO :0008270: zinc ion binding and also this GO :0019901: protein kinase binding and also this GO :0030955: potassium ion binding and also this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific) and also this GO :0033558: protein deacetylase activity and also this GO :0033613: activating transcription factor binding and also this GO :0042826: histone deacetylase binding and also this GO :0043565: sequence-specific DNA binding and also this GO :0044212: transcription regulatory region DNA binding and also this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific) and also this GO :0070491: repressing transcription factor binding and also this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0003677: DNA binding, this GO :0003682: chromatin binding, this GO :0003682: chromatin binding and also this GO :0003714: transcription corepressor activity and also this GO :0004407: histone deacetylase activity and also this GO :0005080: protein kinase C binding and also this GO :0005515: protein binding and also this GO :0019901: protein kinase binding and also this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific) and also this GO :0033613: activating transcription factor binding and also this GO :0046872: metal ion binding and also this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific) and also this GO :0070491: repressing transcription factor binding and also this GO :0071889: 14-3-3 protein binding and also this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0003714: transcription corepressor activity, this GO :0003714: transcription corepressor activity, this GO :0003714: transcription corepressor activity, this GO :0003714: transcription corepressor activity and also this GO :0004407: histone deacetylase activity and also this GO :0005080: protein kinase C binding and also this GO :0005515: protein binding and also this GO :0008134: transcription factor binding and also this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific) and also this GO :0044212: transcription regulatory region DNA binding and also this GO :0046872: metal ion binding and also this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific) and also this GO :0070491: repressing transcription factor binding and also this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0004407: histone deacetylase activity, this GO :0004407: histone deacetylase activity, this GO :0004407: histone deacetylase activity, this GO :0005080: protein kinase C binding, this GO :0005080: protein kinase C binding, this GO :0005515: protein binding, this GO :0005515: protein binding, this GO :0005515: protein binding, this GO :0008134: transcription factor binding, this GO :0008134: transcription factor binding, this GO :0008270: zinc ion binding, this GO :0019901: protein kinase binding, this GO :0019901: protein kinase binding, this GO :0030955: potassium ion binding, this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific), this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific), this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific), this GO :0033558: protein deacetylase activity, this GO :0033613: activating transcription factor binding, this GO :0033613: activating transcription factor binding, this GO :0042826: histone deacetylase binding, this GO :0043565: sequence-specific DNA binding, this GO :0044212: transcription regulatory region DNA binding, this GO :0044212: transcription regulatory region DNA binding, this GO :0046872: metal ion binding, this GO :0046872: metal ion binding, this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific), this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific), this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific), this GO :0070491: repressing transcription factor binding, this GO :0070491: repressing transcription factor binding, this GO :0070491: repressing transcription factor binding, this GO :0071889: 14-3-3 protein binding, this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), histone deacetylase 7 |
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