| Long name | FITC Conjugated, HDAC4(Ser246)/HDAC5(Ser259)/HDAC7(Ser155) Antibody |
| Category | Conjugated Primary Antibodies |
| Conjugation | Anti-FITC Antibody |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | HDAC4 Ser246/HDAC5 Ser259/HDAC7 Ser155 |
| Specificity | This is a highly specific antibody against HDAC4 Ser246/HDAC5 Ser259/HDAC7 Ser155 |
| Modification | Phosphorylation |
| Modification site | Ser155 |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | KLH conjugated synthetic phosphopeptide derived from human HDAC4 around the phosphorylation site of Ser246 |
| Gene ID number | 9759 |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Mouse, Rat, Human |
| Crossreactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background | Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA, It also interacts with myocyte enhancer factor-2 (MEF2) proteins, It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins, It possesses histone deacetylase activity and represses transcription when tethered to a promoter, The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family, This gene is thought to be associated with colon cancer, Two transcript variants encoding different isoforms have been found for this gene, [provided by RefSeq], and developmental events, cell cycle progression, resulting in repression of MEF2-dependent genes, Histones play a critical role in transcriptional regulation |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission | 494nm/518nm |
| Synonyms | DKFZP586J0917 |
| Properties | Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target | HDAC4(Ser246)/HDAC5(Ser259)/HDAC7(Ser155) Conjugated |
| Short name | FITC Conjugated, HDAC4(Ser246)/HDAC5(Ser259)/HDAC7(Ser155) Antibody |
| Technique | Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label | FITC |
| Alternative name | fluorecein coupled, histone deacetylase 4(Ser246)/histone deacetylase 5(Ser259)/histone deacetylase 7(Ser155) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | AHO3 and BDMR and HA6116 and HD4 and HDAC-4 and HDAC-A and HDACA, DNA-templated and biological process this GO :0006954 and inflammatory response and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007507 and heart development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0010830 and regulation of myotube differentiation and biological process this GO :0010832 and negative regulation of myotube differentiation and biological process this GO :0016568 and chromatin modification and biological process this GO :0016575 and histone deacetylation and biological process this GO :0016604 and nuclear body and cellular component this GO :0030183 and B cell differentiation and biological process this GO :0032041 and NAD-dependent histone deacetylase activity (H3-K14 specific) and molecular function this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0033555 and multicellular organismal response to stress and biological process this GO :0042113 and B cell activation and biological process this GO :0042220 and response to cocaine and biological process this GO :0042493 and response to drug and biological process this GO :0043234 and protein complex and cellular component this GO :0043393 and regulation of protein binding and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0006954 and inflammatory response and biological process this GO :0007399 and nervous system development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0010832 and negative regulation of myotube differentiation and biological process this GO :0010882 and regulation of cardiac muscle contraction by calcium ion signaling and biological process this GO :0014894 and response to denervation involved in regulation of muscle adaptation and biological process this GO :0014898 and cardiac muscle hypertrophy in response to stress and biological process this GO :0016568 and chromatin modification and biological process this GO :0016575 and histone deacetylation and biological process this GO :0017053 and transcriptional repressor complex and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0030017 and sarcomere and cellular component this GO :0030018 and Z disc and cellular component this GO :0030183 and B cell differentiation and biological process this GO :0030955 and potassium ion binding and molecular function this GO :0031594 and neuromuscular junction and cellular component this GO :0031672 and A band and cellular component this GO :0032041 and NAD-dependent histone deacetylase activity (H3-K14 specific) and molecular function this GO :0033235 and positive regulation of protein sumoylation and biological process this GO :0033558 and protein deacetylase activity and molecular function this GO :0033613 and activating transcription factor binding and molecular function this GO :0034983 and peptidyl-lysine deacetylation and biological process this GO :0042113 and B cell activation and biological process this GO :0042493 and response to drug and biological process this GO :0042641 and actomyosin and cellular component this GO :0042826 and histone deacetylase binding and molecular function this GO :0043234 and protein complex and cellular component this GO :0043393 and regulation of protein binding and biological process this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045820 and negative regulation of glycolytic process and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0007043 and cell-cell junction assembly and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0016568 and chromatin modification and biological process this GO :0016575 and histone deacetylation and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0032041 and NAD-dependent histone deacetylase activity (H3-K14 specific) and molecular function this GO :0032703 and negative regulation of interleukin-2 production and biological process this GO :0033613 and activating transcription factor binding and molecular function this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0046872 and metal ion binding and molecular function this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0046970 and NAD-dependent histone deacetylase activity (H4-K16 specific) and molecular function this GO :0070491 and repressing transcription factor binding and molecular function this GO :0070932 and histone H3 deacetylation and biological process this GO :0070933 and histone H4 deacetylation and biological process this GO :0071889 and 14-3-3 protein binding and molecular function this GO :0090050 and positive regulation of cell migration involved in sprouting angiogenesis and biological process this GO :0097372 and NAD-dependent histone deacetylase activity (H3-K18 specific) and molecular function, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046872 and metal ion binding and molecular function this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0046970 and NAD-dependent histone deacetylase activity (H4-K16 specific) and molecular function this GO :0048742 and regulation of skeletal muscle fiber development and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051153 and regulation of striated muscle cell differentiation and biological process this GO :0070491 and repressing transcription factor binding and molecular function this GO :0070932 and histone H3 deacetylation and biological process this GO :0070933 and histone H4 deacetylation and biological process this GO :0090051 and negative regulation of cell migration involved in sprouting angiogenesis and biological process this GO :0097372 and NAD-dependent histone deacetylase activity (H3-K18 specific) and molecular function, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0046970 and NAD-dependent histone deacetylase activity (H4-K16 specific) and molecular function this GO :0048742 and regulation of skeletal muscle fiber development and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051153 and regulation of striated muscle cell differentiation and biological process this GO :0070491 and repressing transcription factor binding and molecular function this GO :0070555 and response to interleukin-1 and biological process this GO :0070932 and histone H3 deacetylation and biological process this GO :0070933 and histone H4 deacetylation and biological process this GO :0097372 and NAD-dependent histone deacetylase activity (H3-K18 specific) and molecular function, HD5 and NY-CO-9, HDAC4 and IDBG-642244 and ENSBTAG00000017764 and 517559, HDAC4 and IDBG-84594 and ENSG00000068024 and 9759, HDAC5 and IDBG-53295 and ENSG00000108840 and 10014, HDAC5 and IDBG-640847 and ENSBTAG00000016254 and 504242, HDAC7 and IDBG-29060 and ENSG00000061273 and 51564, HDAC7 and IDBG-633011 and ENSBTAG00000026819 and 509843, Hdac4 and IDBG-181579 and ENSMUSG00000026313 and 208727, Hdac5 and IDBG-212520 and ENSMUSG00000008855 and 15184, Hdac7 and IDBG-179042 and ENSMUSG00000022475 and 56233, NAD-dependent histone deacetylase activity (H3-K18 specific), NAD-dependent histone deacetylase activity (H3-K18 specific), NAD-dependent histone deacetylase activity (H3-K18 specific), histone deacetylase 4, histone deacetylase 5, nuclei, nuclei, nuclei, this GO :0000118 and histone deacetylase complex and cellular component this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001047 and core promoter binding and molecular function this GO :0001501 and skeletal system development and biological process this GO :0002076 and osteoblast development and biological process this GO :0003677 and DNA binding and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006338 and chromatin remodeling and biological process this GO :0006351 and transcription, this GO :0000118 and histone deacetylase complex and cellular component this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001570 and vasculogenesis and biological process this GO :0003682 and chromatin binding and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006351 and transcription, this GO :0000118 and histone deacetylase complex and cellular component this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0002076 and osteoblast development and biological process this GO :0003714 and transcription corepressor activity and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0006325 and chromatin organization and biological process this GO :0006338 and chromatin remodeling and biological process this GO :0006342 and chromatin silencing and biological process this GO :0006351 and transcription, this GO :0001047: core promoter binding, this GO :0001047: core promoter binding and also this GO :0003677: DNA binding and also this GO :0003714: transcription corepressor activity and also this GO :0004407: histone deacetylase activity and also this GO :0005515: protein binding and also this GO :0008134: transcription factor binding and also this GO :0008270: zinc ion binding and also this GO :0019901: protein kinase binding and also this GO :0030955: potassium ion binding and also this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific) and also this GO :0033558: protein deacetylase activity and also this GO :0033613: activating transcription factor binding and also this GO :0042826: histone deacetylase binding and also this GO :0043565: sequence-specific DNA binding and also this GO :0044212: transcription regulatory region DNA binding and also this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific) and also this GO :0070491: repressing transcription factor binding and also this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0003677: DNA binding, this GO :0003682: chromatin binding, this GO :0003682: chromatin binding and also this GO :0003714: transcription corepressor activity and also this GO :0004407: histone deacetylase activity and also this GO :0005080: protein kinase C binding and also this GO :0005515: protein binding and also this GO :0019901: protein kinase binding and also this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific) and also this GO :0033613: activating transcription factor binding and also this GO :0046872: metal ion binding and also this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific) and also this GO :0070491: repressing transcription factor binding and also this GO :0071889: 14-3-3 protein binding and also this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0003714: transcription corepressor activity, this GO :0003714: transcription corepressor activity, this GO :0003714: transcription corepressor activity, this GO :0003714: transcription corepressor activity and also this GO :0004407: histone deacetylase activity and also this GO :0005080: protein kinase C binding and also this GO :0005515: protein binding and also this GO :0008134: transcription factor binding and also this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific) and also this GO :0044212: transcription regulatory region DNA binding and also this GO :0046872: metal ion binding and also this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific) and also this GO :0070491: repressing transcription factor binding and also this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0004407: histone deacetylase activity, this GO :0004407: histone deacetylase activity, this GO :0004407: histone deacetylase activity, this GO :0005080: protein kinase C binding, this GO :0005080: protein kinase C binding, this GO :0005515: protein binding, this GO :0005515: protein binding, this GO :0005515: protein binding, this GO :0008134: transcription factor binding, this GO :0008134: transcription factor binding, this GO :0008270: zinc ion binding, this GO :0019901: protein kinase binding, this GO :0019901: protein kinase binding, this GO :0030955: potassium ion binding, this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific), this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific), this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific), this GO :0033558: protein deacetylase activity, this GO :0033613: activating transcription factor binding, this GO :0033613: activating transcription factor binding, this GO :0042826: histone deacetylase binding, this GO :0043565: sequence-specific DNA binding, this GO :0044212: transcription regulatory region DNA binding, this GO :0044212: transcription regulatory region DNA binding, this GO :0046872: metal ion binding, this GO :0046872: metal ion binding, this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific), this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific), this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific), this GO :0070491: repressing transcription factor binding, this GO :0070491: repressing transcription factor binding, this GO :0070491: repressing transcription factor binding, this GO :0071889: 14-3-3 protein binding, this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), histone deacetylase 7 |
| Identity | 14067 |
| Gene | HDAC7 |
| Long gene name | histone deacetylase 7 |
| Synonyms gene | HDAC7A |
| Synonyms gene name | histone deacetylase 7A |
| Locus | 12q13, 11 |
| Discovery year | 2001-07-13 |
| GenBank acession | AF239243 |
| Entrez gene record | 51564 |
| Pubmed identfication | 10922406 10640276 |
| Classification | Histone deacetylases, class IIA |
| Havana BLAST/BLAT | OTTHUMG00000152968 |
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