| Long name | ALEXA FLUOR 647 Conjugated, HDAC7 (Ser358) Polyclonal Antibody |
| Also known as | Anti-HDAC7 Ser358 PAb ALEXA FLUOR 647 |
| Category | Conjugated Primary Antibodies |
| Conjugated with | 647, ALEXA FLUOR® |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | HDAC7 Ser358 |
| Specificity | This is a highly specific antibody against HDAC7 Ser358 |
| Modification | Phosphorylation |
| Modification Site | Ser358 |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | KLH conjugated synthetic phosphopeptide derived from human HDAC7 around the phosphorylation site of Ser358 |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Mouse, Rat, Human |
| Cross-reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen | Although HDAC7 is localized mostly to the cell nucleus, HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, Human HDAC7 is composed of 912 amino acid residues, It is an active component of different transcriptional corepressor complexes that can be recruited to specific promoter regions via interactions with a growing number of sequence specific transcriptional factors, The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus, it is also found in the cytoplasm, leading to the inhibition of gene transcription, suggesting nucleo-cytoplasmic shuttling, which plays an important role in modulating the eukaryotic chromatin structure, HDAC7 is a member of the class II mammalian histone deacetylases |
| Purification | Purified by Protein A |
| Storage conditions | 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission | 650nm/665nm |
| Synonyms | DKFZP586J0917 |
| Properties | ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the HDAC7 (Ser358) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation | ALEXA FLUOR 647, Alexa Fluor |
| Gene target | HDAC7 (Ser358) |
| Short name | HDAC7 (Ser358) Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Label | ALEXA FLUOR 647 |
| Alternative name | ALEXA FLUOR 647, histone deacetylase 7 (Ser358) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0007043 and cell-cell junction assembly and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0016568 and chromatin modification and biological process this GO :0016575 and histone deacetylation and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0032041 and NAD-dependent histone deacetylase activity (H3-K14 specific) and molecular function this GO :0032703 and negative regulation of interleukin-2 production and biological process this GO :0033613 and activating transcription factor binding and molecular function this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0046872 and metal ion binding and molecular function this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0046970 and NAD-dependent histone deacetylase activity (H4-K16 specific) and molecular function this GO :0070491 and repressing transcription factor binding and molecular function this GO :0070932 and histone H3 deacetylation and biological process this GO :0070933 and histone H4 deacetylation and biological process this GO :0071889 and 14-3-3 protein binding and molecular function this GO :0090050 and positive regulation of cell migration involved in sprouting angiogenesis and biological process this GO :0097372 and NAD-dependent histone deacetylase activity (H3-K18 specific) and molecular function, HDAC7 and IDBG-29060 and ENSG00000061273 and 51564, HDAC7 and IDBG-633011 and ENSBTAG00000026819 and 509843, Hdac7 and IDBG-179042 and ENSMUSG00000022475 and 56233, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, this GO :0000118 and histone deacetylase complex and cellular component this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001570 and vasculogenesis and biological process this GO :0003682 and chromatin binding and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006351 and transcription, this GO :0003682: chromatin binding, this GO :0003682: chromatin binding and also this GO :0003714: transcription corepressor activity and also this GO :0004407: histone deacetylase activity and also this GO :0005080: protein kinase C binding and also this GO :0005515: protein binding and also this GO :0019901: protein kinase binding and also this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific) and also this GO :0033613: activating transcription factor binding and also this GO :0046872: metal ion binding and also this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific) and also this GO :0070491: repressing transcription factor binding and also this GO :0071889: 14-3-3 protein binding and also this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0003714: transcription corepressor activity, this GO :0004407: histone deacetylase activity, this GO :0005080: protein kinase C binding, this GO :0005515: protein binding, this GO :0019901: protein kinase binding, this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific), this GO :0033613: activating transcription factor binding, this GO :0046872: metal ion binding, this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific), this GO :0070491: repressing transcription factor binding, this GO :0071889: 14-3-3 protein binding, this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), histone deacetylase 7 |
| Identity | 14067 |
| Gene | HDAC7 |
| Long gene name | histone deacetylase 7 |
| Synonyms gene | HDAC7A |
| Synonyms gene name | histone deacetylase 7A |
| Locus | 12q13, 11 |
| Discovery year | 2001-07-13 |
| GenBank acession | AF239243 |
| Entrez gene record | 51564 |
| Pubmed identfication | 10922406 10640276 |
| Classification | Histone deacetylases, class IIA |
| Havana BLAST/BLAT | OTTHUMG00000152968 |
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