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HDAC7(Ser486) Antibody

HDAC7(Ser486) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHDAC7(Ser486) Primary Polyclonal Antibody
Also known asHDAC7(Ser486) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHDAC7 Ser486
SpecificityThis is a highly specific antibody against HDAC7 Ser486
Modification(s)Phosphorylation
Modification site(s)Ser486
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Subcellular locationMitochondrion
SourceKLH conjugated synthetic phosphopeptide derived from human HDAC4 around the phosphorylation site of Ser632
Gene ID number51564
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Although HDAC7 is localized mostly to the cell nucleus, HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, Human HDAC7 is composed of 912 amino acid residues, It is an active component of different transcriptional corepressor complexes that can be recruited to specific promoter regions via interactions with a growing number of sequence specific transcriptional factors, The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus, it is also found in the cytoplasm, leading to the inhibition of gene transcription, suggesting nucleo-cytoplasmic shuttling, which plays an important role in modulating the eukaryotic chromatin structure, HDAC7 is a member of the class II mammalian histone deacetylases
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DKFZP586J0917, FLJ99588, HD 7a, HD7a, HDAC 7, HDAC 7A, HDAC7, HDAC7 phospho Ser486, HDAC7A, HDAC7_HUMAN, Histone deacetylase 7, Histone deacetylase 7A, OTTHUMP00000202813, OTTHUMP00000202814, p-HDAC7 Ser486, HDAC7 phospho S486
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHDAC7(Ser486)
Short nameHDAC7(Ser486) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namehistone deacetylase 7(Ser486) (Antibody to)
Alternative techniqueantibodies
Alternative to gene target DNA-templated and biological process this GO :0007043 and cell-cell junction assembly and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0016568 and chromatin modification and biological process this GO :0016575 and histone deacetylation and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0032041 and NAD-dependent histone deacetylase activity (H3-K14 specific) and molecular function this GO :0032703 and negative regulation of interleukin-2 production and biological process this GO :0033613 and activating transcription factor binding and molecular function this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0046872 and metal ion binding and molecular function this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0046970 and NAD-dependent histone deacetylase activity (H4-K16 specific) and molecular function this GO :0070491 and repressing transcription factor binding and molecular function this GO :0070932 and histone H3 deacetylation and biological process this GO :0070933 and histone H4 deacetylation and biological process this GO :0071889 and 14-3-3 protein binding and molecular function this GO :0090050 and positive regulation of cell migration involved in sprouting angiogenesis and biological process this GO :0097372 and NAD-dependent histone deacetylase activity (H3-K18 specific) and molecular function, HDAC7 and IDBG-29060 and ENSG00000061273 and 51564, HDAC7 and IDBG-633011 and ENSBTAG00000026819 and 509843, Hdac7 and IDBG-179042 and ENSMUSG00000022475 and 56233, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, this GO :0000118 and histone deacetylase complex and cellular component this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001570 and vasculogenesis and biological process this GO :0003682 and chromatin binding and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006351 and transcription, this GO :0003682: chromatin binding, this GO :0003682: chromatin binding and also this GO :0003714: transcription corepressor activity and also this GO :0004407: histone deacetylase activity and also this GO :0005080: protein kinase C binding and also this GO :0005515: protein binding and also this GO :0019901: protein kinase binding and also this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific) and also this GO :0033613: activating transcription factor binding and also this GO :0046872: metal ion binding and also this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific) and also this GO :0070491: repressing transcription factor binding and also this GO :0071889: 14-3-3 protein binding and also this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0003714: transcription corepressor activity, this GO :0004407: histone deacetylase activity, this GO :0005080: protein kinase C binding, this GO :0005515: protein binding, this GO :0019901: protein kinase binding, this GO :0032041: NAD-dependent histone deacetylase activity (H3-K14 specific), this GO :0033613: activating transcription factor binding, this GO :0046872: metal ion binding, this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0046970: NAD-dependent histone deacetylase activity (H4-K16 specific), this GO :0070491: repressing transcription factor binding, this GO :0071889: 14-3-3 protein binding, this GO :0097372: NAD-dependent histone deacetylase activity (H3-K18 specific), histone deacetylase 7
Identity 14067
Gene HDAC7
Long gene name histone deacetylase 7
Synonyms gene HDAC7A
Synonyms gene name histone deacetylase 7A
Synonyms DKFZP586J0917
Locus 12q13, 11
Discovery year 2001-07-13
GenBank acession AF239243
Entrez gene record 51564
Pubmed identfication 10922406 10640276
Classification Histone deacetylases, class IIA
Havana BLAST/BLAT OTTHUMG00000152968

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