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HER2 (Tyr1222) Antibody

HER2 (Tyr1222) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHER2 (Tyr1222) Primary Polyclonal Antibody
Also known asHER2 (Tyr1222) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHER2 Tyr1222
SpecificityThis is a highly specific antibody against HER2 Tyr1222
Modification(s)Phosphorylation
Modification site(s)Tyr1222
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human HER2 around the phosphorylation site of Tyr1222
Gene ID number2064
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, Alternative splicing results in several additional transcript variants, Amplification and/or overexpression of this gene has been reported in numerous cancers, However, Ile654/Ile655, Jul 2008], This protein has no ligand binding domain of its own and therefore cannot bind growth factors, [provided by RefSeq, including breast and ovarian tumors, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, shown here, some encoding different isoforms and others that have not been fully characterized, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase, with the most common allele, This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names C erbB 2, C-erbB2, CD340, CD340 antigen, Cerb B2/neu protein, CerbB2, ERBB2_HUMAN, Erb B2, HER 2, HER 2/neu, HER2, HER2Tyr1221/Tyr1222, Her2/neu, Herstatin, MLN 19, MLN19, NEU, NEU Proto Oncogene, NGL, Neuro Glioblastoma Derived Oncogene Homolog, Neuroblastoma/glioblastoma derived oncogene homolog, Receptor Protein Tyrosine Kinase ErbB2 Precursor, Receptor tyrosine protein kinase erbB 2, TKR1, c erb B2, erbb2, p-ErbB 2 phospho Y1222, p185 ErbB2, p185erbB2, ErbB 2 phospho Y1222, ErbB2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHER2 (Tyr1222)
Short nameHER2 (Tyr1222) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHER2 (Tyr1222) (Antibody to)
Alternative techniqueantibodies
Identity 3430
Gene ERBB2
Long gene name erb-b2 receptor tyrosine kinase 2
Synonyms gene NGL
Synonyms gene name v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Synonyms NEU HER-2 CD340 HER2
Synonyms name neuro/glioblastoma derived oncogene homolog human epidermal growth factor receptor 2
Locus 17q12
Discovery year 2001-06-22
GenBank acession X03363
Entrez gene record 2064
RefSeq identity NM_004448
Classification CD molecules Minor histocompatibility antigens Erb-b2 receptor tyrosine kinases
Havana BLAST/BLAT OTTHUMG00000179300
Locus Specific Databases LRG_724

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