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HER3(Tyr1328) Antibody, ALEXA FLUOR 555

HER3(Tyr1328) Antibody, ALEXA FLUOR 555 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 555 Conjugated, HER3(Tyr1328) Polyclonal Antibody
Also known asAnti-HER3 Tyr1328 PAb ALEXA FLUOR 555
CategoryConjugated Primary Antibodies
Conjugated with 555, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenHER3 Tyr1328
SpecificityThis is a highly specific antibody against HER3 Tyr1328
ModificationPhosphorylation
Modification SiteTyr1328
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range1305-1342/1342
Subcellular locationCytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human HER3 around the phosphorylation site of Tyr1328 [PD(p-Y)WH]
Gene ID Number2065
Swiss ProtP21860
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Additional splice variants have also been reported but they have not been thoroughly characterized, Alternate transcriptional splice variants encoding different isoforms have been characterized, Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2), ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain, Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation, However it does form heterodimers with other EGF receptor family members which do have kinase activity, Isoform 2 lacks the intermembrane region and is secreted outside the cell, It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation, LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord, This form acts to modulate the activity of the membrane-bound form, also called Israeli Bedouin multiple contracture syndrome type A, bladder and breast tumors, ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission553nm/568nm
Synonyms HER3
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 555, Alexa Fluor
Gene targetHER3(Tyr1328)
Short nameHER3(Tyr1328) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 555
Alternative name ALEXA FLUOR 555, HER3(Tyr1328) (Antibody to)
Alternative techniqueantibodies
Identity 3431
Gene ERBB3
Long gene name erb-b2 receptor tyrosine kinase 3
Synonyms gene LCCS2
Synonyms gene name lethal congenital contracture syndrome 2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Synonyms name human epidermal growth factor receptor 3
Locus 12q13, 2
Discovery year 1990-07-15
GenBank acession M34309
Entrez gene record 2065
RefSeq identity NM_001982
Classification Erb-b2 receptor tyrosine kinases
Havana BLAST/BLAT OTTHUMG00000170140
Locus Specific Databases LRG_996

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