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HER3(Tyr1328) Antibody, Cy3 Conjugated

HER3(Tyr1328) Antibody, Cy3 Conjugated size: 0.1ml 368

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 368
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy3 Conjugated, HER3(Tyr1328) Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugationcy3 conjugation kit
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenHER3 Tyr1328
SpecificityThis is a highly specific antibody against HER3 Tyr1328
ModificationPhosphorylation
Modification siteTyr1328
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range1305-1342/1342
Subcellular locationCytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human HER3 around the phosphorylation site of Tyr1328 [PD(p-Y)WH]
Gene ID number2065
Swiss ProtP21860
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Additional splice variants have also been reported but they have not been thoroughly characterized, Alternate transcriptional splice variants encoding different isoforms have been characterized, Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2), ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain, Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation, However it does form heterodimers with other EGF receptor family members which do have kinase activity, Isoform 2 lacks the intermembrane region and is secreted outside the cell, It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation, LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord, This form acts to modulate the activity of the membrane-bound form, also called Israeli Bedouin multiple contracture syndrome type A, bladder and breast tumors, ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission512, 550nm/570, 615nm
Synonyms HER3
Properties 1 of the HER3(Tyr1328) Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetHER3(Tyr1328) Conjugated
Short name Conjugated, HER3(Tyr1328) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy3
Alternative name cyanine 3 coupled, HER3(Tyr1328) (Antibody to)
Alternative techniqueantibodies
Identity 3431
Gene ERBB3
Long gene name erb-b2 receptor tyrosine kinase 3
Synonyms gene LCCS2
Synonyms gene name lethal congenital contracture syndrome 2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Synonyms name human epidermal growth factor receptor 3
Locus 12q13, 2
Discovery year 1990-07-15
GenBank acession M34309
Entrez gene record 2065
RefSeq identity NM_001982
Classification Erb-b2 receptor tyrosine kinases
Havana BLAST/BLAT OTTHUMG00000170140
Locus Specific Databases LRG_996

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