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HER4/ErbB4 Antibody

HER4/ErbB4 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHER4/ErbB4 Primary Polyclonal Antibody
Also known asHER4/ErbB4 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHER4/ErbB4
SpecificityThis is a highly specific antibody against HER4/ErbB4
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range460-510/1308
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HER4/ErbB4
Gene ID number2066
Swiss ProtQ15303
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as cell-surface receptor for the neuregulins NRG1, EREG and HBEGF, Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1, Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors, Ligand specificity and signaling is modulated by alternative splicing, Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1, NRG2, NRG3 and NRG4 and the EGF family members BTC, Required for mammary gland differentiation, Required for normal cardiac muscle differentiation during embryonic development, Required for normal development of the embryonic central nervous system, and by the formation of heterodimers with other ERBB family members, and do not promote reorganization of the actin cytoskeleton and cell migration, and for postnatal cardiomyocyte proliferation, and hence do not phosphorylate PIK3R1, cell proliferation, differentiation, do not protect cells against apoptosis, especially for normal neural crest cell migration and normal axon guidance, gene transcription, induction of milk proteins and lactation, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis, migration and apoptosis, proteolytic processing, the central nervous system and the mammary gland, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses, Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ALS19, ERBB4, Proto-oncogene-like protein c-ErbB-4, Receptor tyrosine-protein kinase erbB-4, Tyrosine kinase-type cell surface receptor HER4, p180erbB4, HER4
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHER4/ErbB4
Short nameHER4/ErbB4 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHER4/v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (Antibody to)
Alternative techniqueantibodies
Identity 3432
Gene ERBB4
Long gene name erb-b2 receptor tyrosine kinase 4
Synonyms gene name v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
Synonyms ALS19 HER4
Synonyms name human epidermal growth factor receptor 4
Locus 2q34
Discovery year 1995-09-07
GenBank acession L07868
Entrez gene record 2066
Pubmed identfication 7700649 17018285
RefSeq identity NM_001042599
Classification Erb-b2 receptor tyrosine kinases
Havana BLAST/BLAT OTTHUMG00000133012

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