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HES4 Antibody

HES4 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHES4 Primary Polyclonal Antibody
Also known asHES4 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHES4
SpecificityThis is a highly specific antibody against HES4
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HES4
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen HES1 and HES2 are expressed in a variety of adult and embryonic tissues, HES1-6, HES2 binds to both N and E box sites, HES3 is expressed exclusively in cerebellar Purkinje cells, HES6 inhibits HES1 activity, HES6 is produced in brain as well as in the limb buds of developing embryos, Most HES family members, Rather, The HES family members form a complex with TLE, The HES/TLE complex functions by directly binding to DNA, The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, and HES5 is found solely in the nervous system, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins, including HES1 and HES5, instead of interfering with activator proteins, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG), the mammalian homologue of Groucho, thereby promoting transcription, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis, while HES6 does not bind DNA, The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names HES4_HUMAN, Hairy and enhancer of split 4, Transcription factor HES 4, bHLH factor Hes4
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHES4
Short nameHES4 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHES4 (Antibody to)
Alternative techniqueantibodies
Identity 24149
Gene HES4
Long gene name hes family bHLH transcription factor 4
Synonyms gene name hairy and enhancer of split 4 (Drosophila)
Synonyms bHLHb42
Locus 1p36, 33
Discovery year 2004-09-30
GenBank acession BC012351
Entrez gene record 57801
Pubmed identfication 11260262 15254753
RefSeq identity NM_021170
Classification Basic helix-loop-helix proteins
Havana BLAST/BLAT OTTHUMG00000040758

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