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HFE/Hemochromatosis Antibody, ALEXA FLUOR 350

HFE/Hemochromatosis Antibody, ALEXA FLUOR 350 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 350 Conjugated, HFE/Hemochromatosis Polyclonal Antibody
Also known asAnti-HFE/Hemochromatosis PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated with 350, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenHFE/Hemochromatosis
SpecificityThis is a highly specific antibody against HFE/Hemochromatosis
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HFE/Hemochromatosis
Gene ID Number3077
Tested applications IF(IHC-P), FCM
Recommended dilutions IF(IHC-P)(1:50-200), FCM(1:20-100)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Immunocytochemistry shows that the HFE protein and TfR both are expressed in the crypt enterocytes, In placenta, It is proposed that HFE has two mutually exclusive activities in cells: inhibition of uptake or inhibition of release of iron and that the balance between serum transferrin saturation and serum transferrin-receptor concentrations determines which of these functions predominates, Since hemochromatosis is a relatively easily treated disorder if diagnosed, The HFE protein, The gene which encodes HFE maps to human chromosome 6p21, Western blots show that, and heart failure, as is the case in human placenta, diabetes, hypermelanotic pigmentation of the skin, normally is expressed in crypt enterocytes of the duodenum where it has a unique, predominantly intracellular localization, providing a link between the HFE protein and iron transport, the HFE protein co-localizes with and forms a stable association with the transferrin receptor (TfR), the HFE protein in crypt enterocytes is physically associated with the TfR and with Î, this is a form of preventable cancer, which is defective in hereditary hemo-chromatosis, ², 2-microglobulin, 3, The features of hemochromatosis include cirrhosis of the liver
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission343nm/442nm
Synonyms HLA-H
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 350, Alexa Fluor
Gene targetHFE/Hemochromatosis
Short nameHFE/Hemochromatosis Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 350
Alternative name ALEXA FLUOR 350, hemochromatosis/Hemochromatosis (Antibody to)
Alternative techniqueantibodies
Alternative to gene target BT, HFE and IDBG-67372 and ENSG00000010704 and 3077, HFE1 and HH and HLA-H and MVCD7 and TFQTL2, Hfe and IDBG-136751 and ENSMUSG00000006611 and 15216, Plasma membranes, peptide antigen binding, this GO :0001916 and positive regulation of T cell mediated cytotoxicity and biological process this GO :0002474 and antigen processing and presentation of peptide antigen via MHC class I and biological process this GO :0005102 and receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005769 and early endosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006461 and protein complex assembly and biological process this GO :0006879 and cellular iron ion homeostasis and biological process this GO :0006955 and immune response and biological process this GO :0007565 and female pregnancy and biological process this GO :0010106 and cellular response to iron ion starvation and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0019882 and antigen processing and presentation and biological process this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0042446 and hormone biosynthetic process and biological process this GO :0042605 and peptide antigen binding and molecular function this GO :0042612 and MHC class I protein complex and cellular component this GO :0045177 and apical part of cell and cellular component this GO :0045178 and basal part of cell and cellular component this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0055037 and recycling endosome and cellular component this GO :0055072 and iron ion homeostasis and biological process this GO :0060586 and multicellular organismal iron ion homeostasis and biological process this GO :0097459 and iron ion import into cell and biological process, this GO :0005102: receptor binding, this GO :0005102: receptor binding and also this GO :0005515: protein binding and also this GO :0042605: peptide antigen binding, this GO :0005515: protein binding, this GO :0042605: peptide antigen binding, 37142 and IDBG-635416 and ENSBTAG00000013065 and 497622, hemochromatosis
Identity 4886
Gene HFE
Long gene name hemochromatosis
Synonyms name high Fe
Locus 6p22, 2
Discovery year 1986-01-01
Entrez gene record 3077
Pubmed identfication 3460331
Classification C1-set domain containing
Havana BLAST/BLAT OTTHUMG00000016348
Locus Specific Databases ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_748

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