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HIC1 Antibody

HIC1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHIC1 Primary Polyclonal Antibody
Also known asHIC1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHIC1
SpecificityThis is a highly specific antibody against HIC1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HIC1
Gene ID number3090
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Conversely, HIC-1 does not interact with components of the HDAC complex, HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), HIC-1 is ubiquitously expressed in adult tissues and its structure is defined by five zinc fingers and an N-terminal broad complex POZ (or BTB) domain, In several BTB/POZ containing proteins, These and other studies indicate that HIC-1 acts as a putative tumor suppressor protein that mediates transcriptional repression, When this domain is deleted, and the expression of HIC-1 is also frequently suppressed in leukemia and various cancers due to the hypermethylation of specific DNA regions and the resulting transcriptional silencing, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, suggesting that HIC-1-induced transcriptional repression is unassociated with the POZ/BTB domain, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription, this transcriptional repression is attenuated, Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names HIC1_HUMAN, Hic-1, Hic1, Hypermethylated in cancer 1, Hypermethylated in cancer 1 protein, ZBTB29, ZNF901, Zinc finger and BTB domain-containing protein 29, Hic 1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHIC1
Short nameHIC1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHIC1 (Antibody to)
Alternative techniqueantibodies
Identity 4909
Gene HIC1
Long gene name HIC ZBTB transcriptional repressor 1
Synonyms gene name hypermethylated in cancer 1
Synonyms ZBTB29 ZNF901
Locus 17p13, 3
Discovery year 1996-03-19
Entrez gene record 3090
RefSeq identity NM_006497
Classification BTB domain containing Zinc fingers C2H2-type
Havana BLAST/BLAT OTTHUMG00000177635

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