HIC1 Antibody, Cy5.5 Conjugated

HIC1 Antibody, Cy5.5 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1

Price 350

Size 0.1ml

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Long name	Cy5, 5 Conjugated, HIC1 Polyclonal Antibody
Category	Conjugated Primary Antibodies
Conjugation	Cy5, 5, 5, Cy5
Host Organism	Rabbit (Oryctolagus cuniculus)
Target Antigen	HIC1
Specificity	This is a highly specific antibody against HIC1
Modification	Unmodified
Modification site	None
Clonality	Polyclonal
Clone	Polyclonal antibody
Concentration	1ug per 1ul
Source	KLH conjugated synthetic peptide derived from human HIC1
Gene ID number	3090
Tested applications	IF(IHC-P)
Recommended dilutions	IF(IHC-P)(1:50-200)
Crossreactivity	Mouse, Rat, Human
Crossreactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background	Conversely, HIC-1 does not interact with components of the HDAC complex, HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), HIC-1 is ubiquitously expressed in adult tissues and its structure is defined by five zinc fingers and an N-terminal broad complex POZ (or BTB) domain, In several BTB/POZ containing proteins, These and other studies indicate that HIC-1 acts as a putative tumor suppressor protein that mediates transcriptional repression, When this domain is deleted, and the expression of HIC-1 is also frequently suppressed in leukemia and various cancers due to the hypermethylation of specific DNA regions and the resulting transcriptional silencing, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, suggesting that HIC-1-induced transcriptional repression is unassociated with the POZ/BTB domain, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription, this transcriptional repression is attenuated, Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission	675nm/694nm
Synonyms	ZBTB29 ZNF901
Properties	Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Conjugated	These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths
Gene target	HIC1 Conjugated
Short name	Conjugated, HIC1 Antibody
Technique	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label	5, Cy5
Alternative name	cyanine 5, 5 coupled, HIC1 (Antibody to)
Alternative technique	antibodies
Identity	4909
Gene	HIC1
Long gene name	HIC ZBTB transcriptional repressor 1
Synonyms gene name	hypermethylated in cancer 1
Locus	17p13, 3
Discovery year	1996-03-19
Entrez gene record	3090
RefSeq identity	NM_006497
Classification	BTB domain containing Zinc fingers C2H2-type
Havana BLAST/BLAT	OTTHUMG00000177635

HIC1 Antibody, Cy5.5 Conjugated

HIC1 Antibody, Cy5.5 Conjugated size: 0.1ml 350

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