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HIF-1 Alpha Antibody

HIF-1 Alpha Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHIF-1 Alpha Primary Polyclonal Antibody
Also known asHIF-1 Alpha PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHIF-1 Alpha
SpecificityThis is a highly specific antibody against HIF-1 Alpha
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range351-400/826
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human of human HIF-1 Alpha
Gene ID number3091
Swiss ProtQ16665
Tested Applications IF(ICC), IF(IHC-P), IHC-P, WB
Recommended dilutions IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activation requires recruitment of transcriptional coactivators such as CREBPB and EP3, Activity is enhanced by interaction with both, Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters, HILPDA, Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP, Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia, NCOA1 or NCOA2, Plays an essential role in embryonic vascularization, Under hypoxic conditions, activates the transcription of over 4 genes, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia, glucose transporters, glycolytic enzymes, including erythropoietin, tumor angiogenesis and pathophysiology of ischemic disease, vascular endothelial growth factor, Functions as a master transcriptional regulator of the adaptive response to hypoxia
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1-ALPHA, HIF1A, Hypoxia-inducible factor 1-alpha, MOP1, Member of PAS protein 1, PAS domain-containing protein 8, PASD8, bHLHe78, HIF1
Description- or alpha protein sometimes glycoprotein present in blood, The HIF-1 Alpha Antibody is a &alpha
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHIF-1 Alpha
Short nameHIF-1 Alpha Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHIF-1 a (Antibody to)
Alternative techniqueantibodies
Identity 18420
Gene SETD2
Long gene name SET domain containing 2
Synonyms HYPB HIF-1 KIAA1732 FLJ23184 KMT3A
Locus 3p21, 31
Discovery year 2006-02-15
GenBank acession AJ238403
Entrez gene record 29072
Pubmed identfication 16118227 11461154
RefSeq identity NM_014159
Classification Lysine methyltransferases
Havana BLAST/BLAT OTTHUMG00000133514
Locus Specific Databases LRG_775

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