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HIP12 Antibody, Biotin Conjugated

HIP12 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, HIP12 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenHIP12
SpecificityThis is a highly specific antibody against HIP12
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human HIP1R/HIP12/HIP3
Gene ID number9026
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background HIP1, HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, HIP1 is ubiquitously expressed in different brain regions at low levels and exhibits nearly identical subcellular fractionation as huntingtin, HIP1 may be involved in vesicle trafficking, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level, HIP12 does not directly interact with huntingtin but can interact with HIP1, HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1, However, The HIP1 gene locates to the human chromosome 7q11, The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, a central coiled-coil forming region and an N-terminal ENTH domain, a membrane-associated protein, binds specifically to the N-terminus of human huntingtin, greater than 35 repeats, huntingtin, in the HD gene product, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain, the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo, 23, Huntington disease is associated with the expansion of a polyglutamine tract
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms KIAA0655 HIP3 HIP12 FLJ14000 ILWEQ
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetHIP12 Conjugated
Short name Conjugated, HIP12 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, HIP12 (Antibody to)
Alternative techniqueantibodies
Identity 18415
Gene HIP1R
Long gene name huntingtin interacting protein 1 related
Locus 12q24, 31
Discovery year 2006-01-23
GenBank acession AB013384
Entrez gene record 9026
Pubmed identfication 16415883
RefSeq identity NM_003959
Havana BLAST/BLAT OTTHUMG00000168765

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