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HLA-DPB1 Antibody (MHC II)

HLA-DPB1 Antibody (MHC II) size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenHLA-DPB1 (MHC II)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions5-1ug/ml, Western blot: 0
NotesOptimal dilution of the HLA-DPB1 antibody should be determined by the researcher
Added buffer025% sodium azide, 5% BSA and 0, Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2
Intented useThis antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P04440
PurityAntigen affinity
Description Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, DP (W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene, Exon one encodes the leader peptide, HLA-DPB belongs to the HLA class II beta chain paralogues, It plays a central role in the immune system by presenting peptides derived from extracellular proteins, The beta chain is approximately 26-28 kDa and its gene contains 6 exons, This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, both anchored in the membrane, dendritic cells, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail, exons 2 and 3 encode the two extracellular domains, macrophages), resulting in up to 4 different molecules, HLA class II histocompatibility antigen
ImmunogenA human HLA-DPB1 recombinant protein corresponding to amino acids R30-A258 was used as the immunogen for the HLA-DPB1 antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the HLA-DPB1 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetHLA-DPB1 (MHC II)
Short nameHLA-DPB1 Antibody (MHC II)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name DP b 1 (Antibody to) (Major histocompabitility complex II), class II, major histocompatibility aggregate
Alternative techniqueantibodies
Alternative to gene target Cell surfaces, DP beta 1, DPB1 and HLA-DP and HLA-DP1B and HLA-DPB, HLA-DPB1 and IDBG-230487 and ENSG00000223865 and 3115, class II, peptide antigen binding, this GO :0000139 and this GO lgi membrane and cellular component this GO :0002504 and antigen processing and presentation of peptide or polysaccharide antigen via MHC class II and biological process this GO :0005515 and protein binding and molecular function this GO :0005765 and lysosomal membrane and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0009986 and cell surface and cellular component this GO :0010008 and endosome membrane and cellular component this GO :0012507 and ER to this GO lgi transport vesicle membrane and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019882 and antigen processing and presentation and biological process this GO :0019886 and antigen processing and presentation of exogenous peptide antigen via MHC class II and biological process this GO :0030658 and transport vesicle membrane and cellular component this GO :0030666 and endocytic vesicle membrane and cellular component this GO :0030669 and clathrin-coated endocytic vesicle membrane and cellular component this GO :0031295 and T cell costimulation and biological process this GO :0032588 and trans- this GO lgi network membrane and cellular component this GO :0032729 and positive regulation of interferon-gamma production and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0042605 and peptide antigen binding and molecular function this GO :0042613 and MHC class II protein complex and cellular component this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050870 and positive regulation of T cell activation and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0071556 and integral component of lumenal side of endoplasmic reticulum membrane and cellular component, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0042605: peptide antigen binding, this GO :0042605: peptide antigen binding, major histocompatibility complex
Identity 4940
Gene HLA-DPB1
Long gene name DP beta 1 , class II, major histocompatibility complex
Synonyms gene HLA-DP1B
Locus 6p21, 32
Discovery year 2001-06-22
Entrez gene record 3115
RefSeq identity NM_002121
Classification C1-set domain containing Histocompatibility complex
Havana BLAST/BLAT OTTHUMG00000031076
Locus Specific Databases IMGT/HLA Database

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