| Long name | HMGB1 Primary Polyclonal Antibody |
| Also known as | HMGB1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | HMGB1 |
| Specificity | This is a highly specific antibody against HMGB1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 60-110/215 |
| Subcellular location | Nucleus |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HMGB1 |
| Gene ID number | 3146 |
| Swiss Prot | P09429 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS), Binds preferentially single-stranded DNA, Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity), Involved in V(D)J recombination by acting as a cofactor of the RAG complex, DNA binding proteins that associates with chromatin and has the ability to bend DNA |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | HMG-1, HMG3, HMGB1, High mobility group protein 1, High mobility group protein B1, SBP-1, HMG1 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | HMGB1 |
| Short name | HMGB1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | high mobility family box 1 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | DNA binding, DNA ligation and biological process this GO :0006309 and apoptotic DNA fragmentation and biological process this GO :0006310 and DNA recombination and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006915 and apoptotic process and biological process this GO :0006921 and cellular component disassembly involved in execution phase of apoptosis and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008301 and DNA binding, HMG1 and HMG3 and SBP-1, HMGB1 and IDBG-21100 and ENSG00000189403 and 3146, HMGB1 and IDBG-630533 and ENSBTAG00000018103 and 282691, Hmgb1 and IDBG-209311 and ENSMUSG00000066551 and 100862258, bending, bending and also this GO :0042056: chemoattractant activity and also this GO :0044822: poly(A) RNA binding and also this GO :0050786: RAGE receptor binding and also this GO :0070491: repressing transcription factor binding, bending and molecular function this GO :0009986 and cell surface and cellular component this GO :0017053 and transcriptional repressor complex and cellular component this GO :0017055 and negative regulation of RNA polymerase II transcriptional preinitiation complex assembly and biological process this GO :0031175 and neuron projection development and biological process this GO :0033151 and V(D)J recombination and biological process this GO :0042056 and chemoattractant activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043280 and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0043388 and positive regulation of DNA binding and biological process this GO :0044822 and poly(A) RNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0050786 and RAGE receptor binding and molecular function this GO :0050918 and positive chemotaxis and biological process this GO :0051103 and DNA ligation involved in DNA repair and biological process this GO :0070491 and repressing transcription factor binding and molecular function this GO :2000426 and negative regulation of apoptotic cell clearance and biological process, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000793 and condensed chromosome and cellular component this GO :0001773 and myeloid dendritic cell activation and biological process this GO :0002407 and dendritic cell chemotaxis and biological process this GO :0002437 and inflammatory response to antigenic stimulus and biological process this GO :0003677 and DNA binding and molecular function this GO :0003684 and damaged DNA binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0003697 and single-stranded DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005125 and cytokine activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0006265 and DNA topological change and biological process this GO :0006288 and base-excision repair, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003684: damaged DNA binding and also this GO :0003690: double-stranded DNA binding and also this GO :0003697: single-stranded DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0005125: cytokine activity and also this GO :0005515: protein binding and also this GO :0008134: transcription factor binding and also this GO :0008301: DNA binding, this GO :0003684: damaged DNA binding, this GO :0003690: double-stranded DNA binding, this GO :0003697: single-stranded DNA binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0005125: cytokine activity, this GO :0005515: protein binding, this GO :0008134: transcription factor binding, this GO :0008301: DNA binding, this GO :0042056: chemoattractant activity, this GO :0044822: poly(A) RNA binding, this GO :0050786: RAGE receptor binding, this GO :0070491: repressing transcription factor binding, 15289, 619937, 102642363, high mobility group box 1 |
| Identity | 4983 |
| Gene | HMGB1 |
| Long gene name | high mobility group box 1 |
| Synonyms gene | HMG1 |
| Synonyms gene name | high-mobility group (nonhistone chromosomal) protein 1 high-mobility group box 1 |
| Synonyms | HMG3 SBP-1 DKFZp686A04236 |
| Synonyms name | high mobility group box 1 Sulfoglucuronyl carbohydrate binding protein Amphoterin high mobility group protein 1 |
| Locus | 13q12, 3 |
| Discovery year | 1993-12-13 |
| GenBank acession | D63874 |
| Entrez gene record | 3146 |
| Pubmed identfication | 8661151 11279268 |
| RefSeq identity | NM_002128 |
| Classification | Canonical high mobility group |
| Havana BLAST/BLAT | OTTHUMG00000016670 |
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