Filters

HNF3 alpha Antibody

HNF3 alpha Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHNF3 alpha Primary Polyclonal Antibody
Also known asHNF3 alpha PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHNF3 alpha
SpecificityThis is a highly specific antibody against HNF3 alpha
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range145-185/472
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FOXA1
Gene ID number3169
Swiss ProtP55317
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity), FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity), Interacts with the cis-acting regulatory regions of these genes, Involved in cell cycle regulation by activating expression of CDKN1B, Involved in glucose homeostasis, Involved in regulation of apoptosis by inhibiting the expression of BCL2, Involved in the development of multiple endoderm-derived organ systems such as liver, Is involved in ESR1-mediated transcription, Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites, Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes, Modulates the transcriptional activity of nuclear hormone receptors, Originally described as a transcription activator for a number of liver genes such as AFP, PEPCK, Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs, albumin, alone or in conjunction with BRCA1, binds to the RPRM promter and is required for the estrogen-induced repression of RPRM, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues, etc, lung and prostate, pancreas, required for ESR1 binding to the NKX2-1 promoter in breast cancer cells, tyrosine aminotransferase, Transcription factor that is involved in embryonic development
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names FOXA1, Forkhead box protein A1, HNF-3-alpha, HNF-3A, Hepatocyte nuclear factor 3-alpha, TCF-3A, TCF3A, Transcription factor 3A, HNF3A
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHNF3 alpha
Short nameHNF3 alpha Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHNF3 a (Antibody to)
Alternative techniqueantibodies

Similar products

Subscribe to our Newsletter