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HNF3 alpha Antibody, ALEXA FLUOR 594

HNF3 alpha Antibody, ALEXA FLUOR 594 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 594 Conjugated, HNF3 alpha Polyclonal Antibody
Also known asAnti-HNF3 alpha PAb ALEXA FLUOR 594
CategoryConjugated Primary Antibodies
Conjugated with 594, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenHNF3 alpha
SpecificityThis is a highly specific antibody against HNF3 alpha
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range145-185/472
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FOXA1
Gene ID Number3169
Swiss ProtP55317
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity), FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity), Interacts with the cis-acting regulatory regions of these genes, Involved in cell cycle regulation by activating expression of CDKN1B, Involved in glucose homeostasis, Involved in regulation of apoptosis by inhibiting the expression of BCL2, Involved in the development of multiple endoderm-derived organ systems such as liver, Is involved in ESR1-mediated transcription, Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites, Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes, Modulates the transcriptional activity of nuclear hormone receptors, Originally described as a transcription activator for a number of liver genes such as AFP, PEPCK, Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs, albumin, alone or in conjunction with BRCA1, binds to the RPRM promter and is required for the estrogen-induced repression of RPRM, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues, etc, lung and prostate, pancreas, required for ESR1 binding to the NKX2-1 promoter in breast cancer cells, tyrosine aminotransferase, Transcription factor that is involved in embryonic development
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission590nm/617nm
Synonyms FOXA1, Forkhead box protein A1, HNF-3-alpha, HNF-3A, Hepatocyte nuclear factor 3-alpha, TCF-3A, TCF3A, Transcription factor 3A, HNF3A
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation 594, ALEXA FLUOR®, Alexa Fluor
ConjugatedAlexa conjugate 1
Gene targetHNF3 alpha
Short nameHNF3 alpha Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 594
Alternative name ALEXA FLUOR 594, HNF3 a (Antibody to)
Alternative techniqueantibodies

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