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HNF3 alpha Antibody, FITC Conjugated

HNF3 alpha Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, HNF3 alpha Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenHNF3 alpha
SpecificityThis is a highly specific antibody against HNF3 alpha
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range145-185/472
Subcellular locationNucleus
SourceKLH conjugated synthetic peptide derived from human FOXA1
Gene ID number3169
Swiss ProtP55317
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity), FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity), Interacts with the cis-acting regulatory regions of these genes, Involved in cell cycle regulation by activating expression of CDKN1B, Involved in glucose homeostasis, Involved in regulation of apoptosis by inhibiting the expression of BCL2, Involved in the development of multiple endoderm-derived organ systems such as liver, Is involved in ESR1-mediated transcription, Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites, Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes, Modulates the transcriptional activity of nuclear hormone receptors, Originally described as a transcription activator for a number of liver genes such as AFP, PEPCK, Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs, albumin, alone or in conjunction with BRCA1, binds to the RPRM promter and is required for the estrogen-induced repression of RPRM, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues, etc, lung and prostate, pancreas, required for ESR1 binding to the NKX2-1 promoter in breast cancer cells, tyrosine aminotransferase, Transcription factor that is involved in embryonic development
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms FOXA1, Forkhead box protein A1, HNF-3-alpha, HNF-3A, Hepatocyte nuclear factor 3-alpha, TCF-3A, TCF3A, Transcription factor 3A, HNF3A
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetHNF3 alpha Conjugated
Short name FITC Conjugated, HNF3 alpha Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, HNF3 a (Antibody to)
Alternative techniqueantibodies

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