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HPV16 E6 protein (2E3) Monoclonal Antibody

HPV16 E6 protein (2E3) Monoclonal Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHPV16 E6 protein (2E3) Monoclonal Antibody
Also known asHPV16 E6 protein (2E3) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHPV16 E6 protein
SpecificityThis is a highly specific antibody against HPV16 E6 protein
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number2000
Concentration1ug per 1ul
Immunogen range85-158/158
SourceKLH conjugated synthetic peptide derived from HPV16 E6 protein
Gene ID number1489078
Swiss ProtP03126
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivityVirus
Cross reactive species detailsHPV16
Background of the target antigen Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development, E6 also inhibits immune response by interacting with host IRF3 and TYK2, E6 associates with host E6-AP ubiquitin-protein ligase, Fas-associated death domain-containing protein (FADD) and procaspase 8, In turn, Other cellular targets including Bak, The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization, These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway, a repressor of human telomerase reverse transcriptase (hTERT), and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation, are degraded by E6/E6AP causing inhibition of apoptosis, Plays a major role in the induction and maintenance of cellular transformation
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names E6, Protein E6
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetHPV16 E6 protein (2E3) Monoclonal
Short nameHPV16 E6 protein (2E3) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative nameHPV16 E6 protein (2E3) monoclonal (Antibody to)
Alternative techniqueantibodies

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