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HPV16 E6 protein Antibody

HPV16 E6 protein Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHPV16 E6 protein Primary Polyclonal Antibody
Also known asHPV16 E6 protein PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHPV16 E6 protein
SpecificityThis is a highly specific antibody against HPV16 E6 protein
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range100-150/158
Subcellular locationNucleus
Sourcesynthetic peptide from HPV16-E6 conjugated to KLH
Gene ID number1489078
Swiss ProtP03126
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivityVirus
Cross reactive species detailsHPV16
Background of the target antigen Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development, E6 also inhibits immune response by interacting with host IRF3 and TYK2, E6 associates with host E6-AP ubiquitin-protein ligase, Fas-associated death domain-containing protein (FADD) and procaspase 8, In turn, Other cellular targets including Bak, The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization, These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway, a repressor of human telomerase reverse transcriptase (hTERT), and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation, are degraded by E6/E6AP causing inhibition of apoptosis, Plays a major role in the induction and maintenance of cellular transformation
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names E6 protein, HPV16 E6, HPV16 E6 protein, HPV16-E6, Human Papilloma Virus, Human papillomavirus type 16, Human papillomavirus type 16 E6, Protein E6, VE6_HPV16, E6
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHPV16 E6 protein
Short nameHPV16 E6 protein Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHPV16 E6 protein (Antibody to)
Alternative techniqueantibodies

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