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HPV16 E6 protein Antibody, Biotin Conjugated

HPV16 E6 protein Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, HPV16 E6 protein Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenHPV16 E6 protein
SpecificityThis is a highly specific antibody against HPV16 E6 protein
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range100-150/158
Subcellular locationNucleus
Sourcesynthetic peptide from HPV16-E6 conjugated to KLH
Gene ID number1489078
Swiss ProtP03126
Tested applicationsIHC-P
Recommended dilutionsIHC-P(1:100-500)
CrossreactivityVirus
Crossreactive species detailsHPV16
Antigen background Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development, E6 also inhibits immune response by interacting with host IRF3 and TYK2, E6 associates with host E6-AP ubiquitin-protein ligase, Fas-associated death domain-containing protein (FADD) and procaspase 8, In turn, Other cellular targets including Bak, The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization, These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway, a repressor of human telomerase reverse transcriptase (hTERT), and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation, are degraded by E6/E6AP causing inhibition of apoptosis, Plays a major role in the induction and maintenance of cellular transformation
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms E6 protein, HPV16 E6, HPV16 E6 protein, HPV16-E6, Human Papilloma Virus, Human papillomavirus type 16, Human papillomavirus type 16 E6, Protein E6, VE6_HPV16, E6
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetHPV16 E6 protein Conjugated
Short name Conjugated, HPV16 E6 protein Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, HPV16 E6 protein (Antibody to)
Alternative techniqueantibodies

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