HSP27 Antibody, Biotin Conjugated

HSP27 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1

Price 333

Size 0.1ml

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Long name	Biotin Conjugated, HSP27 Polyclonal Antibody
Category	Conjugated Primary Antibodies
Conjugation	Biotinylated
Host Organism	Rabbit (Oryctolagus cuniculus)
Target Antigen	HSP27
Specificity	This is a highly specific antibody against HSP27
Modification	Unmodified
Modification site	None
Clonality	Polyclonal
Clone	Polyclonal antibody
Concentration	1ug per 1ul
Immunogen_range	100-150/205
Subcellular location	Nucleus, Cytoplasm
Source	KLH conjugated synthetic peptide derived from human HSP27
Gene ID number	3315
Swiss Prot	P04792
Tested applications	IHC-P, WB
Recommended dilutions	IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity	Mouse, Rat, Human
Crossreactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background	A major function of these proteins is to serve as chaperones that bind to and stabilize the active conformation of other proteins, Akt (PKB), Another complex consists of HSP27 and the IKK complex, Cytoplasmic HSP27 exists in multiple complexes, HSP27, HSP27 is also an actin capping protein that binds to the barbed (growing) ends of actin filaments, HSP27 is localized to the cytoplasm of unstressed cells but can redistribute to the nucleus in response to stress, MAPKAP-kinase 2, One complex consists of HSP27, Phosphorylation of HSP27 on serine 82 by MAPKAP-kinase 2 leads to HSP27 dissociation from the Akt/MAPKAP-kinase 2/p38 complex and from actin filaments, The presence of HSP27 in this complex is required for Akt activation by stress stimuli, along with other members of the small HSP group, and p38 MAPK, and stimulates HSP27 binding to the IKK complex, possesses a C-terminal Alpha-crystalline homology domain, thereby inhibiting filament extension, where it may function to stabilize DNA and/or the nuclear membrane, Heat Shock Protein 27 (HSP27) is a 27 kDa member of a family of proteins whose expression and function are stimulated by heat shock and other stress stimuli
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission	N/A
Synonyms	HSP27 HSP28 Hs, 76067 Hsp25 CMT2F
Properties	Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target	HSP27 Conjugated
Short name	Conjugated, HSP27 Antibody
Technique	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label	Biotin
Alternative name	biotinilated coupled, HSP27 (Antibody to)
Alternative technique	antibodies
Identity	5246
Gene	HSPB1
Long gene name	heat shock protein family B (small) member 1
Synonyms gene name	heat shock 27kD protein 1 heat shock 27kDa protein 1
Locus	7q11, 23
Discovery year	1991-07-09
GenBank acession	X54079
Entrez gene record	3315
Pubmed identfication	2243808 9344682
Classification	Small heat shock proteins
Havana BLAST/BLAT	OTTHUMG00000023228
Locus Specific Databases	Inherited Peripheral Neuropathies Mutation Database LRG_248

HSP27 Antibody, Biotin Conjugated

HSP27 Antibody, Biotin Conjugated size: 0.1ml 333

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