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HSP27 (Ser15) Antibody

HSP27 (Ser15) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHSP27 (Ser15) Primary Polyclonal Antibody
Also known asHSP27 (Ser15) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHSP27 Ser15
SpecificityThis is a highly specific antibody against HSP27 Ser15
Modification(s)Phosphorylation
Modification site(s)Ser15
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human HSP27 around the phosphorylation site of Ser15
Gene ID number3315
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Because of the estrogen responsive nature of Hsp27, Hsp27, Hsp27 synthesis is induced by elevated temperature, Interestingly, MAP3K2/MEKK2, Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, This protein is involved in stress resistance and actin organization, This work has led to the suggestion that Hsp27 may be a useful marker in classifying various hormone sensitive tumors, [provided by RefSeq], also referred to as the Estrogen regulated 24K protein and HSP28, and MAP4K2/GCK, and environmental stresses, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, as well as estrogen in hormone responsive cells, but only one transcript variant has been supported and defined, endometrium and breast tissue, human HSP27 also shares greater than 50% homology with low molecular weight Drosophila HSP's and mammalian a-crystalline lens protein, is one of several small heat shock proteins (HSP) produced by all organisms studied, this protein has been studied extensively in human estrogen responsive tissues such as cervix, MAP3K3/MEKK5, The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names 28 kDa heat shock protein, CMT2F, DKFZp586P1322, Estrogen regulated 24 kDa protein, Estrogen-regulated 24 kDa protein, HMN2B, HS, HSP27, HSPB1_HUMAN, Heat Shock Protein 27, Heat Shock Protein 27, Heat Shock Protein27, Heat Shock Protein27, Heat shock 25kDa protein 1, Heat shock 25kDa protein 1, Heat shock 27 kDa protein, Heat shock 27kD protein 1, Heat shock 27kDa protein 1, Heat shock 27kDa protein 1, Heat shock 28kDa protein 1, Heat shock 28kDa protein 1, Heat shock protein beta 1, Heat shock protein beta-1, Hsp 25, Hsp 25, Hsp 27, Hsp 27, Hsp 28, Hsp 28, Hsp B1, Hsp B1, Hsp25, Hsp25, Hsp28, Hsp28, HspB1, HspB1, SRP27, Stress responsive protein 27, Stress-responsive protein 27, 76067, HSP27Ser15, Heat shock 27kDa protein
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHSP27 (Ser15)
Short nameHSP27 (Ser15) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHSP27 (Ser15) (Antibody to)
Alternative techniqueantibodies
Identity 5246
Gene HSPB1
Long gene name heat shock protein family B (small) member 1
Synonyms gene name heat shock 27kD protein 1 heat shock 27kDa protein 1
Synonyms HSP27 HSP28 Hs, 76067 Hsp25 CMT2F
Locus 7q11, 23
Discovery year 1991-07-09
GenBank acession X54079
Entrez gene record 3315
Pubmed identfication 2243808 9344682
Classification Small heat shock proteins
Havana BLAST/BLAT OTTHUMG00000023228
Locus Specific Databases Inherited Peripheral Neuropathies Mutation Database LRG_248

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