Filters

ICOS/CD278 Antibody

ICOS/CD278 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameICOS/CD278 Primary Polyclonal Antibody
Also known asICOS/CD278 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenICOS/CD278
Specificity This antibody may also have a secondary cross-reactivity with AP-1 complex-associated regulatory protein due to a 77% non-contiguous sequence similarity in the corresponding immunogen region, This is a highly specific antibody against ICOS/CD278
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range40-90/199
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ICOS
Gene ID number29851
Swiss ProtQ9Y6W8
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Does not up-regulate the production of interleukin-2, Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens, Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity), Prevents the apoptosis of pre-activated T-cells, and effective help for antibody secretion by B-cells, but superinduces the synthesis of interleukin-10, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, Enhances all basic T-cell responses to a foreign antigen
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Activation-inducible lymphocyte immunomediatory molecule, CD278, CVID1, ICOS, Inducible T-cell costimulator, AILIM
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetICOS/CD278
Short nameICOS/CD278 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameinducible T-cell co-stimulator/CD278 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target Extracellular, ICOS and IDBG-643378 and ENSBTAG00000021596 and 507026, ICOS and IDBG-79246 and ENSG00000163600 and 29851, Icos and IDBG-159737 and ENSMUSG00000026009 and 54167, protein binding, this GO :0002517 and T cell tolerance induction and biological process this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0031295 and T cell costimulation and biological process, this GO :0005515: protein binding, this GO :0005515: protein binding, inducible T-cell co-stimulator
Identity 5351
Gene ICOS
Long gene name inducible T-cell costimulator
Synonyms AILIM CD278
Synonyms name activation-inducible lymphocyte immunomediatory molecule
Locus 2q33, 2
Discovery year 2000-02-29
GenBank acession AB023135
Entrez gene record 29851
Pubmed identfication 9930702 10617205
RefSeq identity NM_012092
Classification CD molecules
Havana BLAST/BLAT OTTHUMG00000132880
Locus Specific Databases ICOSbase: Mutation registry for ICOS deficiency LRG_65

Similar products

Subscribe to our Newsletter