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ICOS/CD278 Antibody, FITC Conjugated

ICOS/CD278 Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, ICOS/CD278 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenICOS/CD278
Specificity This antibody may also have a secondary cross-reactivity with AP-1 complex-associated regulatory protein due to a 77% non-contiguous sequence similarity in the corresponding immunogen region, This is a highly specific antibody against ICOS/CD278
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range40-90/199
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human ICOS
Gene ID number29851
Swiss ProtQ9Y6W8
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Does not up-regulate the production of interleukin-2, Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens, Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity), Prevents the apoptosis of pre-activated T-cells, and effective help for antibody secretion by B-cells, but superinduces the synthesis of interleukin-10, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, Enhances all basic T-cell responses to a foreign antigen
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms AILIM CD278
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetICOS/CD278 Conjugated
Short name FITC Conjugated, ICOS/CD278 Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, inducible T-cell co-stimulator/CD278 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target Extracellular, ICOS and IDBG-643378 and ENSBTAG00000021596 and 507026, ICOS and IDBG-79246 and ENSG00000163600 and 29851, Icos and IDBG-159737 and ENSMUSG00000026009 and 54167, protein binding, this GO :0002517 and T cell tolerance induction and biological process this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0031295 and T cell costimulation and biological process, this GO :0005515: protein binding, this GO :0005515: protein binding, inducible T-cell co-stimulator
Identity 5351
Gene ICOS
Long gene name inducible T-cell costimulator
Synonyms name activation-inducible lymphocyte immunomediatory molecule
Locus 2q33, 2
Discovery year 2000-02-29
GenBank acession AB023135
Entrez gene record 29851
Pubmed identfication 9930702 10617205
RefSeq identity NM_012092
Classification CD molecules
Havana BLAST/BLAT OTTHUMG00000132880
Locus Specific Databases ICOSbase: Mutation registry for ICOS deficiency LRG_65

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