| Long name | ID2 Primary Polyclonal Antibody |
| Also known as | ID2 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | ID2 |
| Specificity | Due to the similarity of this protein with ID1, this antibody has a chance to have light cross-reactivity with ID1 due to a 77% sequence similarity in the range of our immunogen, This is a highly specific antibody against ID2 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 33-82/134 |
| Subcellular location | Nucleus, Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GIG8/ID2 |
| Gene ID number | 3398 |
| Swiss Prot | Q02363 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Implicated in regulating a variety of cellular processes, Inhibits skeletal muscle and cardiac myocyte differentiation, Plays a role in both the input and output pathways of the circadian clock: in the input component, Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer, Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm, and neoplastic transformation, angiogenesis, apoptosis, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism, differentiation, including cellular growth, is involved in modulating the magnitude of photic entrainment and in the output component, senescence, Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | Class B basic helix-loop-helix protein 26, DNA-binding protein inhibitor ID-2, ID2, ID2A, ID2H, Inhibitor of DNA binding 2, Inhibitor of differentiation 2, bHLHb26, GIG8 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | ID2 |
| Short name | ID2 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | dominant negative helix-loop-helix protein (Antibody to), inhibitor on Desoxyribonucleic acid binding 2 |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0046983 and protein dimerization activity and molecular function this GO :0048468 and cell development and biological process this GO :0048469 and cell maturation and biological process this GO :0048541 and Peyer's patch development and biological process this GO :0048557 and embryonic digestive tract morphogenesis and biological process this GO :0048661 and positive regulation of smooth muscle cell proliferation and biological process this GO :0048663 and neuron fate commitment and biological process this GO :0048711 and positive regulation of astrocyte differentiation and biological process this GO :0048715 and negative regulation of oli this GO dendrocyte differentiation and biological process this GO :0060612 and adipose tissue development and biological process this GO :0060749 and mammary gland alveolus development and biological process this GO :0061030 and epithelial cell differentiation involved in mammary gland alveolus development and biological process this GO :0061031 and endodermal digestive tract morphogenesis and biological process this GO :0071158 and positive regulation of cell cycle arrest and biological process this GO :0071285 and cellular response to lithium ion and biological process this GO :0071931 and positive regulation of transcription involved in G1/S transition of mitotic cell cycle and biological process this GO :0090398 and cellular senescence and biological process this GO :2000045 and regulation of G1/S transition of mitotic cell cycle and biological process this GO :2000178 and negative regulation of neural precursor cell proliferation and biological process, ID2 and IDBG-27111 and ENSG00000115738 and 3398, ID2 and IDBG-638503 and ENSBTAG00000021187 and 505025, Id2 and IDBG-131550 and ENSMUSG00000020644 and 15902, bHLHb26 and GIG8 and ID2A and ID2H, dominant negative helix-loop-helix protein, nuclei, protein dimerization activity, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000785 and chromatin and cellular component this GO :0001656 and metanephros development and biological process this GO :0001779 and natural killer cell differentiation and biological process this GO :0002521 and leukocyte differentiation and biological process this GO :0003149 and membranous septum morphogenesis and biological process this GO :0003166 and bundle of His development and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005813 and centrosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0007275 and multicellular organismal development and biological process this GO :0007507 and heart development and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009649 and entrainment of circadian clock and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0014003 and oli this GO dendrocyte development and biological process this GO :0019216 and regulation of lipid metabolic process and biological process this GO :0021772 and olfactory bulb development and biological process this GO :0032922 and circadian regulation of gene expression and biological process this GO :0033598 and mammary gland epithelial cell proliferation and biological process this GO :0042752 and regulation of circadian rhythm and biological process this GO :0043153 and entrainment of circadian clock by photoperiod and biological process this GO :0043234 and protein complex and cellular component this GO :0043353 and enucleate erythrocyte differentiation and biological process this GO :0043392 and negative regulation of DNA binding and biological process this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0044325 and ion channel binding and molecular function this GO :0045475 and locomotor rhythm and biological process this GO :0045578 and negative regulation of B cell differentiation and biological process this GO :0045600 and positive regulation of fat cell differentiation and biological process this GO :0045648 and positive regulation of erythrocyte differentiation and biological process this GO :0045651 and positive regulation of macrophage differentiation and biological process this GO :0045665 and negative regulation of neuron differentiation and biological process this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045777 and positive regulation of blood pressure and biological process this GO :0045787 and positive regulation of cell cycle and biological process this GO :0045892 and negative regulation of transcription, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0044325: ion channel binding and also this GO :0046983: protein dimerization activity, this GO :0044325: ion channel binding, this GO :0046983: protein dimerization activity, inhibitor of DNA binding 2 |
| Identity | 5361 |
| Gene | ID2 |
| Long gene name | HLH protein , inhibitor of DNA binding 2 |
| Synonyms gene name | dominant negative helix-loop-helix protein , inhibitor of differentiation 2 inhibitor of DNA binding 2 |
| Synonyms | GIG8 bHLHb26 |
| Synonyms name | cell growth-inhibiting gene 8 |
| Locus | 2p25, 1 |
| Discovery year | 1994-12-22 |
| Entrez gene record | 3398 |
| Pubmed identfication | 8294468 |
| RefSeq identity | NM_002166 |
| Classification | Basic helix-loop-helix proteins |
| Havana BLAST/BLAT | OTTHUMG00000112454 |
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