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IFN-beta Antibody

IFN-beta Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameIFN-beta Primary Polyclonal Antibody
Also known asIFN-beta PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenIFN-beta
SpecificityThis is a highly specific antibody against IFN-beta
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from mouse IFN-beta
Gene ID number24481
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Rat, Mouse
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Both IFN subtypes are pleiotropic cytokines and have a similar range of biological activities, Both chains are necessary for function and in the absence of either there is neither high affinity binding nor biological activity, Differences between alpha subtypes, Higher potency of IFN beta in treatment of multiple sclerosis and certain cancers has been observed, IFN beta elicits a markedly higher antiproliferation response in some cell types such as, IFNAR1 and IFNAR2, In particular, Jak1 and Tyk2, The human IFN alphas are encoded by a family of at least 15 different genes, The intracellular portions of the receptor subunits are bound by tyrosine kinases, There is approximately 50% amino acid homology between the alpha and beta subtypes, They are divided into alpha and beta subtypes leukocytes and fibroblasts reactivity, Two chains of the receptor, Type I IFNs signal through binding to a common cell surface receptor, Upon ligand binding these kinases are activated and phosphorylate members of the STAT family of transcription factors, and between IFN alpha and betas, are in potency and cell type specific activities, as well as IFNAR1 and 2, embryonal carcinoma, have been identified, melanoma and melanocytes than do IFN alphas, members of the Janus kinase family, while IFN beta is the unique member of its subtype, The mammalian type I Inteferons (IFN1) are produced in response to viral infection and other inducers
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Î, Î, Î, B, Beta N, Beta-N, F, Interferon beta 1 fibroblast , Interferon beta precursor, Interferon betaï, Interferon-beta, MGC96956ï, N, N Î, N beta, N-Beta, NB , NB 1, NB1, ¼, ¼, &rsaquo, &rsaquo, ², ², ², ², -N, Fibroblast interferon, N
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetIFN-beta
Short nameIFN-beta Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameInterferon-b (Antibody to)
Alternative techniqueantibodies
Identity 5417
Gene IFNA1
Long gene name interferon alpha 1
Synonyms IFNA@ IFL IFN IFN-ALPHA IFNA13 IFN-alphaD
Synonyms name IFN-alpha 1b interferon alpha 1b
Locus 9p21, 3
Discovery year 1993-01-14
Entrez gene record 3439
Pubmed identfication 1385305
RefSeq identity NM_024013
Classification Interferons
Havana BLAST/BLAT OTTHUMG00000019673

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