| Long name | IGFBP3 Primary Polyclonal Antibody |
| Also known as | IGFBP3 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | IGFBP3 |
| Specificity | This is a highly specific antibody against IGFBP3 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 240-296/296 |
| Subcellular location | Secreted |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human IGFBP3 |
| Gene ID number | 3486 |
| Swiss Prot | P17936 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R, They alter the interaction of IGFs with their cell surface receptors, IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | BP-53, IBP-3, IGF-binding protein 3, IGFBP-3, IGFBP3, Insulin-like growth factor-binding protein 3, IBP3 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | IGFBP3 |
| Short name | IGFBP3 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | insulin-like growth factor binding protein 3 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | BP-53 and IBP3, IGFBP3 and IDBG-15809 and ENSG00000146674 and 3486, IGFBP3 and IDBG-633994 and ENSBTAG00000003994 and 282261, Igfbp3 and IDBG-148893 and ENSMUSG00000020427 and 16009, metal ion binding, nuclei, this GO :0001558 and regulation of cell growth and biological process this GO :0001649 and osteoblast differentiation and biological process this GO :0001933 and negative regulation of protein phosphorylation and biological process this GO :0001968 and fibronectin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005520 and insulin-like growth factor binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0008160 and protein tyrosine phosphatase activator activity and molecular function this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009968 and negative regulation of signal transduction and biological process this GO :0010906 and regulation of glucose metabolic process and biological process this GO :0014912 and negative regulation of smooth muscle cell migration and biological process this GO :0016942 and insulin-like growth factor binding protein complex and cellular component this GO :0031994 and insulin-like growth factor I binding and molecular function this GO :0040008 and regulation of growth and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043085 and positive regulation of catalytic activity and biological process this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0043568 and positive regulation of insulin-like growth factor receptor signaling pathway and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0044342 and type B pancreatic cell proliferation and biological process this GO :0045663 and positive regulation of myoblast differentiation and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048662 and negative regulation of smooth muscle cell proliferation and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0001968: fibronectin binding, this GO :0001968: fibronectin binding and also this GO :0005515: protein binding and also this GO :0005520: insulin-like growth factor binding and also this GO :0008160: protein tyrosine phosphatase activator activity and also this GO :0031994: insulin-like growth factor I binding and also this GO :0046872: metal ion binding, this GO :0005515: protein binding, this GO :0005520: insulin-like growth factor binding, this GO :0008160: protein tyrosine phosphatase activator activity, this GO :0031994: insulin-like growth factor I binding, this GO :0046872: metal ion binding, insulin-like growth factor binding protein 3 |
| Identity | 5472 |
| Gene | IGFBP3 |
| Long gene name | insulin like growth factor binding protein 3 |
| Synonyms gene name | insulin-like growth factor binding protein 3 |
| Synonyms | IBP3 BP-53 |
| Synonyms name | growth hormone-dependent binding protein acid stable subunit of the 140 K IGF complex binding protein 53 binding protein 29 IGF-binding protein 3 |
| Locus | 7p12, 3 |
| Discovery year | 1991-07-09 |
| Entrez gene record | 3486 |
| Pubmed identfication | 1695633 |
| RefSeq identity | NM_001013398 |
| Classification | Insulin like growth factor binding proteins |
| Havana BLAST/BLAT | OTTHUMG00000023769 |
| Locus Specific Databases | LRG_68 |
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