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IKAP Antibody

IKAP Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameIKAP Primary Polyclonal Antibody
Also known asIKAP PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenIKAP
SpecificityThis is a highly specific antibody against IKAP
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human IKAP
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activation of NFkB requires that IkB be phosphorylated on specific serine residues, IKAP (IKK-complex-associated protein) is a protein that acts as a scaffold, IKK alpha, IKK alpha and IKK beta and assembling them into an active kinase complex (7, IKK beta and IKK gamma (also designated NEMO), IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines (4), IkB kinase alpha (IKK alpha), Phosphorylation of the IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), The functional IKK complex contains three subunits, and each appears to make essential contributions to IkB phosphorylation (6), interacting with NIK, interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation, previously designated CHUK (2), serines 32 and 36 (3), which itself is a central regulator for NFkB activation in response to TNF and IL-1 (5), which results in the targeted degradation of IkB (1), 8), The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DYS, Dysautonomia Riley Day syndrome hereditary sensory autonomic neuropathy type III, ELP 1, ELP1, ELP1_HUMAN, Elongator complex protein 1, FD, FLJ12497, IKAP, IKI 3, IKI3, IKK complex associated protein, IKK complex-associated protein, IkappaB kinase complex associated protein, IkappaB kinase complex-associated protein, Inhibitor of kappa light polypeptide gene enhancer in B cells kinase complex associated protein, OTTHUMP00000063889, TOT 1, TOT1, ikbkap, p150, DKFZp781H1425
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetIKAP
Short nameIKAP Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameIKAP (Antibody to)
Alternative techniqueantibodies
Identity 5959
Gene IKBKAP
Long gene name inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Synonyms gene DYS
Synonyms gene name dysautonomia (Riley-Day syndrome, hereditary sensory autonomic neuropathy type III)
Synonyms IKAP TOT1 ELP1 IKI3
Synonyms name elongator acetyltransferase complex subunit 1
Locus 9q31, 3
Discovery year 1998-09-30
GenBank acession AF044195
Entrez gene record 8518
Pubmed identfication 9751059 11179008
Classification Elongator acetyltransferase complex
Havana BLAST/BLAT OTTHUMG00000020465
Locus Specific Databases Inherited Peripheral Neuropathies Mutation Database LRG_251

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