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IKK β (42D1) Monoclonal Antibody

IKK β (42D1) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name (42D1) Monoclonal Antibody, IKK &beta
Also known as (42D1) Monoclonal Antibody, IKK &beta
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenIKK &beta
SpecificityThis is a highly specific antibody against IKK &beta
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number42D1
Concentration1ug per 1ul
SourceRecombinant human protein purified from E, coli (His-IKKbeta)
Gene ID number3551
Swiss ProtO14920
Tested ApplicationsWB
Recommended dilutions0 ug/mL), WB (1
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues, Also phosphorylates other substrates including NCOA3, BCL10 and IRS1, DNA damages or other cellular stresses, IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs, In addition to the NF-kappa-B inhibitors, In turn, NF-kappa-B subunits RELA and NFKB1, Phosphorylates FOXO3, These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome, Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation, as well as IKK-related kinases TBK1 and IKBKE, bacterial or viral products, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor, or protection against apoptosis, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-B, IKK-beta, IKKB, IMD15, IkBKB, Inhibitor of nuclear factor kappa-B kinase subunit beta, NFKBIKB, Nuclear factor NF-kappa-B inhibitor kinase beta, IKK2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target (42D1) Monoclonal, IKK &beta
Short name (42D1) Monoclonal Antibody, IKK &beta
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name (42D1) monoclonal (Antibody to), IKK &beta
Alternative techniqueantibodies

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