Filters

IKK alpha/beta (S176 + S180) Antibody, HRP Conjugated

IKK alpha/beta (S176 + S180) Antibody, HRP Conjugated size: 0.1ml 368

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 368
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name HRP Conjugated, IKK alpha/beta (S176 + S180) Antibody
CategoryConjugated Primary Antibodies
ConjugationHRP Conjugated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenIKK alpha/beta Ser176 + Ser180
Specificity These phosphorylation sites are homologous across the listed species, This is a highly specific antibody against IKK alpha/beta Ser176 + Ser180
ModificationPhosphorylation
Modification siteSer176 + Ser180
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range150-200/756
Subcellular locationNucleus
SourceKLH conjugated synthetic phosphopeptide derived from human IKK alpha/beta around the phosphorylation site of Ser176/Ser180
Gene ID number1147
Swiss ProtO15111
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues, Additionally, As part of the non-canonical pathway of NF-kappa-B activation, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation, DNA damages or other cellular stresses, In turn, In turn, Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP, Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK, TAX1BP1, Therefore, These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome, Within the nucleus, and the E3 ligases ITCH and RNF11), bacterial or viral products, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes, or protection against apoptosis, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities, phosphorylates the CREBBP-interacting protein NCOA3, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis, Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% Gentamicin, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms CHUK, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase 1, I-kappa-B kinase alpha, IKBKA, IKK-A, IKK-alpha, IKKA, IkappaB kinase, Inhibitor of nuclear factor kappa-B kinase subunit alpha, NFKBIKA, Nuclear factor NF-kappa-B inhibitor kinase alpha, TCF-16, TCF16, Transcription factor 16, IKK1
Properties Also monoclonal HRP conjugates are often used for Western Blot, HRP conjugates are often primary rabbit polyclonal antibodies couples to the , found in the roots of , (HRP), C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°, enzyme , horseradish, horseradish peroxidase 
Gene targetIKK alpha/beta (S176 + S180) Conjugated
Short name Conjugated, IKK alpha/beta (S176 + S180) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelHRP
Alternative name horseradish peroxidase coupled, IKK a/b (S176 and S180) (Antibody to)
Alternative techniqueantibodies

Similar products

Subscribe to our Newsletter