Filters

IKK alpha / IKKB (Thr23) Antibody

IKK alpha / IKKB (Thr23) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameIKK alpha / IKKB (Thr23) Antibody
Also known asIKK alpha / IKKB (Thr23) Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenIKK alpha / IKKB Thr23
SpecificityThis is a highly specific antibody against IKK alpha / IKKB Thr23
Modification(s)Phosphorylation
Modification site(s)Thr23
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from mouse IKK alpha around the phosphorylation site of Thr23
Gene ID number1147
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues, Additionally, As part of the non-canonical pathway of NF-kappa-B activation, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation, DNA damages or other cellular stresses, In turn, In turn, Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP, Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK, TAX1BP1, Therefore, These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome, Within the nucleus, and the E3 ligases ITCH and RNF11), bacterial or viral products, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes, or protection against apoptosis, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities, phosphorylates the CREBBP-interacting protein NCOA3, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis, Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CHUK, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase 1, I-kappa-B kinase alpha, IKK-A, IKK-alpha, IKK1, IKKA, IkBKA, IkappaB kinase, NFKBIKA, Nuclear factor NF-kappa-B inhibitor kinase alpha, TCF-16, TCF16, Transcription factor 16, Inhibitor of nuclear factor kappa-B kinase subunit alpha
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetIKK alpha / IKKB (Thr23)
Short nameIKK alpha / IKKB (Thr23) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameIKK a / IKKB (Thr23) (Antibody to)
Alternative techniqueantibodies
Identity 5960
Gene IKBKB
Long gene name inhibitor of nuclear factor kappa B kinase subunit beta
Synonyms gene name inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Synonyms IKK2 NFKBIKB IKK-beta IKKB
Locus 8p11, 21
Discovery year 1998-02-11
GenBank acession AF029684
Entrez gene record 3551
Pubmed identfication 9878263 9763654 18308615
Havana BLAST/BLAT OTTHUMG00000164092

Similar products

Subscribe to our Newsletter