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IKK beta(Tyr199) Antibody

IKK beta(Tyr199) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameIKK beta(Tyr199) Primary Polyclonal Antibody
Also known asIKK beta(Tyr199) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenIKK beta Tyr199
Specificity This phosphorylation site is homologous across the listed species, This is a highly specific antibody against IKK beta Tyr199
Modification(s)Phosphorylation
Modification site(s)Tyr199
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range180-230/756
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human IKK beta around the phosphorylation site of Tyr199
Gene ID number3551
Swiss ProtO14920
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues, Also phosphorylates other substrates including NCOA3, BCL10 and IRS1, DNA damages or other cellular stresses, IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs, In addition to the NF-kappa-B inhibitors, In turn, NF-kappa-B subunits RELA and NFKB1, These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome, Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation, as well as IKK-related kinases TBK1 and IKBKE, bacterial or viral products, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-B, IKK-beta, IKKB, IMD15, IkBKB, Inhibitor of nuclear factor kappa-B kinase subunit beta, NFKBIKB, Nuclear factor NF-kappa-B inhibitor kinase beta, IKK2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetIKK beta(Tyr199)
Short nameIKK beta(Tyr199) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameIKK b(Tyr199) (Antibody to)
Alternative techniqueantibodies

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